Pazopanib-induced asymptomatic radiological acute pancreatitis: A case report

Molecular and Clinical Oncology
Iosune BaraibarIgnacio Gil-Bazo

Abstract

The universal clinical use of multi-targeted tyrosine kinase inhibitors (TKIs) in patients diagnosed with advanced renal cell carcinoma (RCC) has significantly prolonged their estimated survival times and their quality of life. However, several adverse side-effects associated predominantly with the inhibition of the vascular endothelial growth factor receptor by these drugs may prove to be potentially life-threatening. One adverse event that is only rarely observed with the use of TKIs in this clinical setting is acute pancreatitis. In the present study, to the best of our knowledge, the first case of asymptomatic radiological acute pancreatitis associated with the use of pazopanib in monotherapy in a patient with RCC is presented. In addition, a comprehensive review of the literature on this topic is provided, and certain potential measures that may aid in early diagnosis and treatment are discussed.

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R J MotzerJ Ferrara
Apr 10, 2007·Mayo Clinic Proceedings·Surabhi AmarWinston W Tan
Mar 10, 2009·Lancet·Brian I RiniBernard Escudier
Jun 27, 2009·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J MotzerJue Wang
Jul 8, 2009·Nature Reviews. Clinical Oncology·Helen X Chen, Jessica N Cleck
Jan 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cora N SternbergRobert E Hawkins
Mar 13, 2010·The Journal of Pathology·Marcella M BaldewijnsAdriaan P de Bruïne
Nov 20, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B EscudierUNKNOWN ESMO Guidelines Working Group
Aug 24, 2013·The New England Journal of Medicine·Robert J MotzerToni K Choueiri
Oct 16, 2013·International Journal of Cancer. Journal International Du Cancer·Matteo SantoniStefano Cascinu
Apr 2, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bernard EscudierDavid Cella
May 3, 2014·The New England Journal of Medicine·Robert J MotzerToni K Choueiri
Oct 3, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J BellmuntI Duran
Dec 30, 2014·Critical Reviews in Oncology/hematology·Pooja GhataliaGuru Sonpavde
May 15, 2015·BMC Research Notes·Marco RussanoDaniele Santini
Oct 16, 2015·Case Reports in Oncology·Kazumichi KawakuboNaoya Sakamoto

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Citations

Nov 14, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Takeshi TanakaYuzo Kodama

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