PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Cindy Yanfei LiJulia Yue Cui

Abstract

Polybrominated diphenyl ethers (PBDEs) are persistent environmental contaminants with well characterized toxicities in host organs. Gut microbiome is increasingly recognized as an important regulator of xenobiotic biotransformation; however, little is known about its interactions with PBDEs. Primary bile acids (BAs) are metabolized by the gut microbiome into more lipophilic secondary BAs that may be absorbed and interact with certain host receptors. The goal of this study was to test our hypothesis that PBDEs cause dysbiosis and aberrant regulation of BA homeostasis. Nine-week-old male C57BL/6 conventional (CV) and germ-free (GF) mice were orally gavaged with corn oil (10 mg/kg), BDE-47 (100 μmol/kg), or BDE-99 (100 μmol/kg) once daily for 4 days (n = 3-5/group). Gut microbiome was characterized using 16S rRNA sequencing of the large intestinal content in CV mice. Both BDE-47 and BDE-99 profoundly decreased the alpha diversity of gut microbiome and differentially regulated 45 bacterial species. Both PBDE congeners increased Akkermansia muciniphila and Erysipelotrichaceae Allobaculum spp., which have been reported to have anti-inflammatory and antiobesity functions. Targeted metabolomics of 56 BAs was conducted in serum, liver, ...Continue Reading

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Citations

May 28, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David K ScovilleJulia Yue Cui
May 19, 2019·Clinical Pharmacology and Therapeutics·Caroline Birer, Erik S Wright
Sep 8, 2020·Expert Review of Gastroenterology & Hepatology·Letícia F RamosKaren C M Moraes
Jul 14, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vicki L SutherlandConnie Chen
Aug 15, 2019·Experimental and Therapeutic Medicine·Qun LiuShiying Xuan
Oct 21, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Matthew V GomezJulia Yue Cui
Dec 15, 2020·Current Pharmacology Reports·Joseph L Dempsey, Julia Yue Cui
Aug 29, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joe Jongpyo LimJulia Yue Cui
Oct 16, 2021·Frontiers in Pharmacology·Tingyu PanHailang He
Dec 17, 2021·Communications Biology·Angela ZhangJulia Yue Cui

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