PBX1 acts as terminal selector for olfactory bulb dopaminergic neurons.

Development
Laura RemesalNuria Flames

Abstract

Neuronal specification is a protracted process that begins with the commitment of progenitor cells and culminates with the generation of mature neurons. Many transcription factors are continuously expressed during this process but it is presently unclear how these factors modify their targets as cells transition through different stages of specification. In olfactory bulb adult neurogenesis, the transcription factor PBX1 controls neurogenesis in progenitor cells and the survival of migrating neuroblasts. Here, we show that, at later differentiation stages, PBX1 also acts as a terminal selector for the dopaminergic neuron fate. PBX1 is also required for the morphological maturation of dopaminergic neurons and to repress alternative interneuron fates, findings that expand the known repertoire of terminal-selector actions. Finally, we reveal that the temporal diversification of PBX1 functions in neuronal specification is achieved, at least in part, through the dynamic regulation of alternative splicing. In Caenorhabditis elegans, PBX/CEH-20 also acts as a dopaminergic neuron terminal selector, which suggests an ancient role for PBX factors in the regulation of terminal differentiation of dopaminergic neurons.

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 23, 2002·Science·Robert J McEvillyMichael G Rosenfeld
Jun 1, 2004·Molecular and Cellular Biology·Licia SelleriMichael L Cleary
Sep 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Claudia Erbel-SielerSteven L McKnight
Sep 29, 2004·Genesis : the Journal of Genetics and Development·Jonas LindebergTed Ebendal
Oct 30, 2004·The Journal of Comparative Neurology·Sachiko Saino-SaitoHarriet Baker
Jun 14, 2005·Nature Neuroscience·Michael A HackMagdalena Götz
Jun 29, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Minoree KohwiArturo Alvarez-Buylla
Jul 7, 2007·Science·Florian T MerkleArturo Alvarez-Buylla
Apr 3, 2008·PloS One·Camille BoutinHarold Cremer
Jun 20, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Monika S BrillMagdalena Götz
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Oliver Hobert
Mar 17, 2009·Nature·Nuria Flames, Oliver Hobert
Apr 14, 2009·Cerebral Cortex·Vitor H SousaGord Fishell
Jan 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emi KiyokageMichael T Shipley
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John W CaveHarriet Baker
Sep 8, 2010·Nature Neuroscience·Chen LiuEvan S Deneris
Jun 23, 2011·Annual Review of Neuroscience·Nuria Flames, Oliver Hobert
Oct 12, 2011·Annual Review of Cell and Developmental Biology·Oliver Hobert
Nov 22, 2011·The European Journal of Neuroscience·Lorenza MagnoThomas Naumann
Mar 1, 2012·Frontiers in Cellular Neuroscience·Antoine de ChevignyChristophe Beclin
May 9, 2012·Developmental Cell·Matthew KossLicia Selleri
Feb 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria BorisovskaGary L Westbrook
May 2, 2013·BMC Biology·Marc NomaksteinskyJean-François Brunet
Jul 23, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·E LongobardiFrancesco Blasi

❮ Previous
Next ❯

Citations

May 3, 2021·The EMBO Journal·Nathalia AlmeidaFrancesca M Spagnoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Q Lu, M P Kamps
Genesis : the Journal of Genetics and Development
Catherine A SchnabelMichael L Cleary
In Vitro Cellular & Developmental Biology. Animal
Anne S JürgensJürgen S Scheele
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
L RedmondM A Morabito
© 2021 Meta ULC. All rights reserved