Pbx1 is essential for growth of zebrafish swim bladder

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Pick-Har TeohWoon-Khiong Chan

Abstract

pbx1, a TALE (three-amino acid loop extension) homeodomain transcription factor, is involved in a diverse range of developmental processes. We examined the expression of pbx1 during zebrafish development by in situ hybridization. pbx1 transcripts could be detected in the central nervous system and pharyngeal arches from 24 hpf onwards. In the swim bladder anlage, pbx1 was detected as early as 28 hpf, making it the earliest known marker for this organ. Morpholino-mediated gene knockdown of pbx1 revealed that the swim bladder failed to inflate, with eventual lethality occurring by 8 dpf. The knockdown of pbx1 did not perturb the expression of prdc and foxA3, with both early swim bladder markers appearing normally at 36 and 48 hpf, respectively. However, the expression of anxa5 was completely abolished by pbx1 knockdown at 60 hpf suggesting that pbx1 may be required during the late stage of swim bladder development.

References

Aug 1, 1992·Nature Genetics·T R Bürglin, G Ruvkun
Dec 1, 1991·Molecular and Cellular Biology·K MonicaM L Cleary
Mar 1, 1994·Respiration Physiology·C B DanielsT E Nicholas
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Apr 18, 1998·The EMBO Journal·J BerthelsenF Blasi
Nov 14, 1998·Biochimica Et Biophysica Acta·R VeldhuizenF Possmayer
Feb 19, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·N VlachakisC G Sagerström
Apr 13, 2000·Connective Tissue Research·S PerrinJ A Foster
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C PremB Pelster
Dec 19, 2000·Mechanisms of Development·C A SchnabelM L Cleary
Feb 22, 2001·Annual Review of Physiology·W V Cardoso
Apr 20, 2002·Differentiation; Research in Biological Diversity·Yi-Wen Liu, Woon-Khiong Chan
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Pamela C Yelick, Thomas F Schilling
Nov 15, 2002·Developmental Cell·Andrew Jan WaskiewiczCecilia B Moens
Dec 20, 2002·Mechanisms of Development·Elke A OberDidier Y R Stainier
Dec 31, 2002·The EMBO Journal·Charlotte Kilstrup-NielsenVincenzo Zappavigna
Feb 20, 2003·Developmental Biology·Catherine A SchnabelMichael L Cleary
Mar 21, 2003·Developmental Biology·Holly A FieldDidier Y R Stainier
Nov 5, 2003·Genesis : the Journal of Genetics and Development·Catherine A SchnabelMichael L Cleary
Feb 24, 2004·Annual Review of Physiology·John M Shannon, Brian A Hyatt
Jun 1, 2004·Molecular and Cellular Biology·Licia SelleriMichael L Cleary
Oct 7, 2004·The American Journal of Pathology·Joon Whan RheeMichael L Cleary
Jun 10, 2005·Development·Andrea BrendolanLicia Selleri
Nov 18, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·F AvaronM A Akimenko
Jan 26, 2006·Gene Expression Patterns : GEP·Giuseppina Di GiacomoLicia Selleri
Feb 25, 2006·The Journal of Comparative Neurology·Jessica L FinneyRoger P Croll
Mar 7, 2006·Developmental Biology·Cecilia B Moens, Licia Selleri
Apr 1, 2006·Molecular and Cellular Endocrinology·Tao LiuTianru Jin
Aug 22, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Iris I MüllerAntonis K Hatzopoulos
Jul 20, 2007·BMC Developmental Biology·Curtis R FrenchAndrew J Waskiewicz

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Citations

Mar 10, 2011·Development·Donghun ShinDidier Y R Stainier
Sep 12, 2015·Molecular Biology of the Cell·Rosa A Uribe, Marianne E Bronner
Mar 1, 2013·Evolution & Development·Amanda N CassAmy R McCune
Jan 16, 2021·Environmental Science & Technology·Sean EverittSteve Wiseman

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