PCAP is the major known prostate cancer predisposing locus in families from south and west Europe

European Journal of Human Genetics : EJHG
G Cancel-TassinOlivier Cussenot

Abstract

To date four prostate cancer predisposing loci have been mapped: HPC1 (Hereditary Prostate Cancer 1) on 1q24-25, PCaP (Predisposing for Cancer Prostate) on 1q42.2-43, CAPB (Cancer Prostate and Brain) on 1p36, and HPCX on Xq27-28. We examined evidence for linkage to those loci in 64 families from south and west Europe. Genotyping of three (six for PCaP) markers encompassing the candidate regions were performed on 221 individuals including 159 affected patients. The resulting data were analysed using both parametric and non parametric linkage methods. No significant evidence of linkage to HPC1, CAPB, or HPCX was found either in the whole population or when pedigrees were stratified according to criteria specific to each locus. By contrast, results in favour of linkage to PCaP locus were observed with maximum multipoint NPL and HLOD scores of 2.8 (P = 0.0026) and 2.65 respectively. Homogeneity analysis performed with multipoint LOD scores gave an estimated proportion of families with linkage to this locus up to 50%. Particularly, families with an earlier age at diagnosis (< or = 65-years-old) contributed significantly to the evidence of linkage with a maximum multipoint NPL score of 2.03 (P = 0.024). Those results suggest that PCa...Continue Reading

References

Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B S CarterP C Walsh
Jan 1, 1990·The Prostate·G D SteinbergP C Walsh
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M LathropJ Ott
Sep 1, 1993·The Journal of Urology·B S CarterP C Walsh
Jul 2, 1997·Journal of the National Cancer Institute·K A CooneyK Lange
Oct 27, 1997·American Journal of Epidemiology·H GrönbergL Iselius
Dec 31, 1997·Journal of the National Cancer Institute·C L HsiehA S Whittemore
Jun 19, 1998·American Journal of Human Genetics·D J SchaidS N Thibodeau
Jun 19, 1998·American Journal of Human Genetics·P BerthonO Cussenot
Mar 3, 1999·American Journal of Human Genetics·M GibbsE A Ostrander
Mar 26, 1999·American Journal of Human Genetics·M GibbsE A Ostrander
Nov 11, 1999·Human Molecular Genetics·S L NeuhausenL A Cannon-Albright
Mar 21, 2000·Genetic Epidemiology·E L GoodeG P Jarvik

❮ Previous
Next ❯

Citations

Jul 4, 2001·International Journal of Cancer. Journal International Du Cancer·G Cancel-TassinO Cussenot
May 27, 2004·Current Urology Reports·Jonathan L Chin, Robert E Reiter
Jun 21, 2012·BMC Medical Genetics·Joan E Bailey-WilsonUNKNOWN International Consortium for Prostate Cancer Genetics
Nov 28, 2013·Nephro-urology Monthly·Evangelos Mazaris, Alexios Tsiotras
Aug 23, 2002·Neoplasia : an International Journal for Oncology Research·Phillippa J NevilleGraham Casey
Sep 8, 2010·Hematology/oncology Clinics of North America·David J GallagherJonathan A Coleman
Jun 5, 2003·BJU International·L E Johns, R S Houlston
Sep 15, 2012·BJU International·Richard M Bambury, David J Gallagher
Dec 19, 2003·The Urologic Clinics of North America·Kisseng Hsieh, Peter C Albertsen
Mar 7, 2013·Free Radical Biology & Medicine·Amélie RebillardJosiane Cillard
Jan 17, 2015·Annales d'endocrinologie·Mawussi AdjaklyDominique Bernard-Gallon
Aug 21, 2002·The Journal of Urology·Ola Bratt
Nov 6, 2003·The Prostate·Douglas F EastonUNKNOWN International Consortium for Prostate Cancer Genetics
May 9, 2006·Current Opinion in Urology·Randi L Shand, Edward P Gelmann
Nov 17, 2005·BJU International·Géraldine Cancel-Tassin, Olivier Cussenot
May 22, 2002·Endocrinology·Jacques SimardFernand Labrie
Mar 29, 2003·Prostate Cancer and Prostatic Diseases·S BevanUNKNOWN CRC/BPG UK Familial Prostate Cancer Study Collaborators
Jun 11, 2004·Médecine sciences : M/S·Olivier Cussenot, Géraldine Cancel-Tassin
Dec 16, 2004·The Prostate·Daniel J SchaidUNKNOWN International Consortium For Prostate Cancer Genetics

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.