PCBs as environmental estrogens: turtle sex determination as a biomarker of environmental contamination

Environmental Health Perspectives
J M BergeronJ A McLachlan

Abstract

Polychlorinated biphenyls (PCBs) are widespread, low-level environmental pollutants associated with adverse health effects such as immune suppression and teratogenicity. There is increasing evidence that some PCB compounds are capable of disrupting reproductive and endocrine function in fish, birds, and mammals, including humans, particularly during development. Research on the mechanism through which these compounds act to alter reproductive function indicates estrogenic activity, whereby the compounds may be altering sexual differentiation. Here we demonstrate the estrogenic effect of some PCBs by reversing gonadal sex in a reptile species that exhibits temperature-dependent sex determination.

References

Apr 1, 1992·The Journal of Endocrinology·T Wibbels, D Crews
Jul 1, 1992·The Journal of Experimental Zoology·T WibbelsD Crews
Dec 1, 1991·The Journal of Experimental Zoology·T WibbelsD Crews
Oct 1, 1991·The Journal of Experimental Zoology·T WibbelsD Crews
Jan 27, 1990·Lancet·J D McKinneyJ A McLachlan
Mar 1, 1991·General and Comparative Endocrinology·D CrewsT Wibbels
Jan 1, 1988·Reproductive Toxicology·A Lione
Jun 1, 1988·General and Comparative Endocrinology·J J BullD Crews
Jan 1, 1994·The Prostate·R SanttiJ A McLachlan
Jul 1, 1993·Differentiation; Research in Biological Diversity·T WibbelsD Crews

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Citations

Dec 22, 1999·General and Comparative Endocrinology·L J GuilletteH F Percival
May 3, 2013·Environmental Science and Pollution Research International·Rouzbeh Tehrani, Benoit Van Aken
Sep 1, 1995·Environmental Health Perspectives·M S Wolff
Oct 1, 1995·Environmental Health Perspectives·D CrewsJ A McLachlan
Oct 1, 1996·Environmental Health Perspectives·S F Arnold, J A McLachlan
Apr 1, 1997·Environmental Health Perspectives·S Steingraber
Jun 1, 1997·Environmental Health Perspectives·M S Wolff, A Weston
Apr 16, 1998·Environmental Health Perspectives·T M CrispY M Patel
May 26, 1998·Environmental Health Perspectives·L Lagadic, T Caquet
Aug 14, 1998·Environmental Health Perspectives·K F ArcaroJ F Gierthy
Dec 23, 1998·Environmental Health Perspectives·D O CarpenterD D Vakharia
Jan 29, 1999·Environmental Health Perspectives·J M BergeronD Crews
Jan 29, 1999·Environmental Health Perspectives·D M SheehanD Crews
Sep 30, 1999·Environmental Health Perspectives·M D Mayes
Aug 4, 2001·Environmental Health Perspectives·A O CheekM Brouwer
Apr 5, 2003·Environmental Health Perspectives·Zhan-Fen QinXiao-Bai Xu
Jun 5, 2003·Environmental Health Perspectives·Allen W Olmstead, Gerald A LeBlanc
Aug 1, 1996·Environmental Health Perspectives·J ToppariN E Skakkebaek
Oct 7, 2003·Environmental Health Perspectives·Carol RiceFrederick S vom Saal
May 4, 2004·Environmental Health Perspectives·Jennifer E FoxJohn A McLachlan
Nov 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·David J OstrachJoe G Zinkl
Oct 13, 2011·Environmental Health Perspectives·Chang WangGuibin Jiang
Oct 30, 1996·Molecular and Cellular Endocrinology·S F ArnoldJ A McLachlan
May 31, 2006·Applied Microbiology and Biotechnology·T YamadaK Kimbara
Nov 18, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Florencia ReyMónica Muñoz-de-Toro
Mar 22, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H TapieroK D Tew
May 25, 2001·Chemosphere·M TakadaR Uchida
Mar 26, 2004·Ecotoxicology and Environmental Safety·S PawlowskiT Braunbeck
Sep 24, 1999·The Science of the Total Environment·S N PedersenP Bjerregaard
Dec 31, 1997·The Science of the Total Environment·P T HarrisonC D Humfrey
May 3, 2011·Bulletin of Environmental Contamination and Toxicology·N A Pelallo-MartínezD J González-Mille
Mar 21, 2012·Bulletin of Environmental Contamination and Toxicology·Shuangying YuDonald W Sparling

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