pCMV-vegf165 Intramuscular Gene Transfer is an Effective Method of Treatment for Patients With Chronic Lower Limb Ischemia

Journal of Cardiovascular Pharmacology and Therapeutics
R V DeevA A Isaev

Abstract

Effective treatment of chronic lower limb ischemia is one of the most challenging issues confronting vascular surgeons. There are a number of choices available to the vascular surgeon. Open or endovascular revascularization is the treatment of choice when applicable. Current pharmacological therapies play an auxiliary role and cannot prevent disease progression. Therefore, new methods of treatment are needed. We conducted a phase 2b/3 multicenter randomized controlled clinical trial of the intramuscular transfer of a plasmid DNA encoding vascular endothelial growth factor (VEGF) 165 with cytomegalovirus promotor (CMV) in patients with atherosclerotic lower limb ischemia. A total of 100 patients were enrolled in the study, that is, 75 patients were randomized into the test group and received 2 intramuscular injections of 1.2 mg of pCMV-vegf165, 14 days apart together with standard pharmacological treatment. In all, 25 patients were randomized into the control group and received standard treatment only. The following end points were evaluated within the first 6 months of the study and during a 1.5-year additional follow-up period: pain-free walking distance (PWD), ankle-brachial index (ABI), and blood flow velocity (BFV). The pCM...Continue Reading

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Citations

Dec 10, 2015·BioMed Research International·R V DeevA A Isaev
Apr 9, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Seppo Ylä-Herttuala, Andrew H Baker
Jan 13, 2018·Frontiers in Endocrinology·Joshua P H NealeDaryl O Schwenke
Jun 9, 2017·The Cochrane Database of Systematic Reviews·Vitali GorenoiAnja Hagen
May 10, 2019·International Journal of Molecular Sciences·Federico BiscettiAndrea Flex
Jul 13, 2019·Circulation. Cardiovascular Imaging·James T Thackeray, Pablo Bascuñana
Jan 12, 2019·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Seyed Rabie MahdaviAhad Alizadeh
May 22, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·John P Cooke, Shu Meng
Aug 11, 2020·Hypertension·Munehisa ShimamuraRyuichi Morishita
Jan 5, 2017·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Roman DeevArtur Isaev
Mar 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karel PetrakVivek A Kumar
Nov 30, 2019·Frontiers in Immunology·Fanni A Boros, László Vécsei
Nov 29, 2016·Case Reports in Dentistry·I Y BozoI I Eremin
May 10, 2019·Frontiers in Oncology·Reena GoswamiVenkaiah Betapudi
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Nov 1, 2018·The Cochrane Database of Systematic Reviews·Rachel ForsterGerard Stansby
Oct 15, 2019·Frontiers in Genetics·Alireza ShahryariHeiko Lickert
Jan 5, 2021·Frontiers in Cell and Developmental Biology·Roya RamezankhaniEnsiyeh Hajizadeh-Saffar
Dec 31, 2019·Biotechnology Advances·Cui-Cui MaYu-Quan Wei
Mar 31, 2021·Drug Discovery Today·Nabil A AlhakamyCory J Berkland
Jun 7, 2021·Cytokine & Growth Factor Reviews·Isabela Gobbo FerreiraEliane Candiani Arantes
Jun 29, 2021·Jornal Vascular Brasileiro·Sang Won HanPaulo Eduardo Ocke Reis

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Methods Mentioned

BETA
amputations
amputation

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