PMID: 9179692Mar 1, 1997Paper

PCNA and p53 in urinary bladder cancer: correlation with histological findings and prognosis

International Journal of Urology : Official Journal of the Japanese Urological Association
T InagakiT Ohkawa

Abstract

This study aimed to immunohistochemically examine the expression of proliferating cell nuclear antigens (PCNA) and p53 protein in transitional cell carcinomas (TCC) of the urinary bladder, and to investigate possible correlations of this expression with the tumor grade or stage, tumor recurrence, and prognosis of the disease. The immunohistochemical status of the PCNA and p53 proteins were determined on paraffin-embedded sections from 128 patients with TCC of the urinary bladder, using PC-10 and DO7 as the primary antibodies. Positive stainings were represented by scores (Labeling Index; LI, %) calculated as the percent of positive cells among all neoplastic cells counted. The findings were compared to the patients' histopathological features. Patients who underwent transurethral resection were divided into groups with "low" and "high" scores for PCNA and p53, respectively, and the tumor recurrence rate was compared among the groups. Patients who underwent total cystectomy were similarly divided into "low" and "high" score groups, and survival rates of the groups were compared. PCNA expression was observed in 66 of 128 patients (51.6%), with a mean labeling index of 26.6%. Overexpression of p53 was observed in 65 of 128 patient...Continue Reading

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Citations

May 27, 2010·Cancer Prevention Research·Randolph StoneJohn L Clifford
Sep 14, 2013·Critical Reviews in Oncology/hematology·Liang ChengShaobo Zhang
Mar 14, 2018·Molecular Medicine Reports·Fucai TangHangtao Wang

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