PMID: 7526146Jul 1, 1994Paper

PCP/NMDA receptor-channel complex and brain development

Neurotoxicology and Teratology
Ratna Sircar, C S Li

Abstract

Phencyclidine (PCP) acts on a variety of neurotransmitter systems--cholinergic, catechoaminergic, indoleaminergic, and peptidergic--but the dose at which it produces its psychotomimetic effects is lower than the concentration at which it affects these systems. At low doses, PCP interacts primarily with a binding site located within the ionophore associated with the NMDA receptor complex--binding to this site has been used as a biochemical marker for NMDA channel activity. PCP/NMDA receptor-channel complex has been shown to play an important role in brain development but little is known of the neurochemical effects following postnatal administration of NMDA antagonists in rats. In the present study, rats were treated with PCP from Day 5 until Day 15 after birth and binding to the PCP receptor was measured on postnatal Day 21 using [3H]MK-801; MK-801 is a more potent and specific ligand at the PCP receptor than PCP itself. Postnatal PCP administration produced specific alterations in PCP receptor binding in 21-day-old rat forebrain. There was a reduction in the high affinity component of [3H]MK-801 binding under baseline binding conditions. In the presence of both L-glutamate and glycine, [3H]MK-801 binding in PCP-treated rats in...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J P VincentM Lazdunski
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S R Zukin, R S Zukin
Jan 17, 1992·Brain Research. Developmental Brain Research·K M Boje, P Skolnick
Nov 7, 1991·Nature·K MoriyoshiS Nakanishi
Dec 1, 1990·Brain Research. Developmental Brain Research·E TremblayY Ben-Ari
Oct 1, 1990·Brain Research. Developmental Brain Research·M A Bowe, J V Nadler
Feb 1, 1990·Brain Research. Developmental Brain Research·G A PaleosJ C Byrd
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D C Javitt, S R Zukin
May 1, 1989·Brain Research. Developmental Brain Research·M D MajewskaE D London
Nov 6, 1989·Neuroscience Letters·K ShinoharaK Takahashi
May 22, 1989·Brain Research·A M MorinD Thomson
May 1, 1989·Brain Research. Developmental Brain Research·S M DudekM F Bear
Jul 1, 1989·Neurotoxicology and Teratology·T A Fico, C Vanderwende
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D T MonaghanC W Cotman
Jan 27, 1988·European Journal of Pharmacology·J Willetts, R L Balster
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R QuirionC B Pert
Oct 1, 1982·Pharmacology, Biochemistry, and Behavior·R QuirionC B Pert
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·S N Pradhan
Jul 1, 1980·Journal of Psychedelic Drugs·R ErardR Peele
Sep 1, 1958·Anesthesia and Analgesia·F E GREIFENSTEINJ E GAJEWSKI
Oct 1, 1961·Comprehensive Psychiatry·C B BAKKER, F B AMINI
Oct 1, 1959·British Journal of Anaesthesia·M JOHNSTONES BAIGEL

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Citations

Sep 29, 1995·Brain Research. Developmental Brain Research·R SircarC S Li
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Ratna Sircar, Karam F A Soliman
Apr 25, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ratna Sircar
Feb 24, 2001·Neurotoxicology and Teratology·J S MeyerR Sircar
Jul 21, 1998·Annals of the New York Academy of Sciences·R Sircar, J W Rudy
Feb 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janne Damm Andersen, Bruno Pouzet
May 13, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Josette S Lindahl, Joyce Keifer
May 1, 1998·Annals of the New York Academy of Sciences·Ratna Sircar, Jerry W Rudy

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