PMID: 8950560Oct 1, 1996Paper

PCR detection of mycobacteraemia in tanzanian patients with extrapulmonary tuberculosis

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
C RichterA H Kolk

Abstract

In 191 Tanzanian patients admitted to hospital with suspected extrapulmonary tuberculosis (TB), TB was diagnosed in 158 patients; the remaining 33 patients had neither microbiological nor clinical evidence of TB. Mycobacterium tuberculosis was detected in the blood of 25 patients, in 92% by a polymerase chain reaction (PCR) technique and in 52% by culture of buffy coat cells. The presence of mycobacterial DNA or Mycobacterium tuberculosis bacteria in peripheral blood (positive culture) was significantly associated with HIV infection; it was detected in 22 (21.4%) of 103 HIV-seropositive patients compared to only 3 (3.5%) of 55 HIV-seronegative patients (p < 0.009). In two-thirds of the patients with mycobacteraemia, TB can be detected by simple smears from other organ sites. In patients with suspected extrapulmonary tuberculosis in whom smears from the infected site are negative or not available, PCR on blood will confirm the diagnosis within 24 hours in one third of the cases.

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Citations

Jun 15, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yu-Shin ChiuYee-Chun Chen
Apr 13, 2005·Seminars in Pediatric Infectious Diseases·Anna M Mandalakas, Jeffrey R Starke
Jul 11, 2016·The Journal of Infection·Christian PohlKlaus Reither
Jan 14, 2018·Scientific Reports·E S ClickK P Cain
May 1, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W SougakoffV Jarlier

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