PMID: 9185075Apr 1, 1997Paper

PCR identification of class I major histocompatibility complex genes transcribed in mouse blastocyst and placenta

Journal of Reproductive Immunology
C P LandelL Q Bundesen

Abstract

We used an RT-PCR based strategy to amplify, clone and sequence MHC class I genes transcribed in the blastocyst and placenta of BALB/c mice. The PCR primers used were capable of amplifying many novel class I sequences from genomic DNA. By comparing the resulting sequence data with known class I sequences, we identified a number of different class I genes transcribed in these tissues. These include H2-K, -D, -L and a novel sequence in blastocysts, and H2-K, -D, -L, -D2, -T9, -T13, -T17, -T18, -M2 and three additional novel sequences in placenta. We postulate that some members of this spectrum of blastocyst and placentally-expressed MHC class Ib genes may act together at the maternal-fetal interface in ways that are important for a successful pregnancy.

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Citations

Sep 11, 2013·Molecular and Cellular Biology·Zohar S BarbashDinah S Singer
Jul 5, 2001·Seminars in Immunology·D A ClarkR M Gorczynski

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