PCR-SSCP analysis of the angiotensin II type 1 receptor gene in patients with aldosterone-producing adenomas

Clinical and Experimental Pharmacology & Physiology
S A KlemmR D Gordon

Abstract

1. In patients with primary aldosteronism due to angiotensin-responsive and angiotensin-unresponsive aldosterone-producing adenomas, no differences in the coding region of the angiotensin II type 1 (AT1) receptor gene were observed compared to normal subjects in peripheral blood leucocyte DNA. 2. Furthermore, no differences in the AT1 receptor gene were observed in DNA extracted from tumour tissue of either subgroup. 3. Genotypic and allelic frequencies for an RFLP detected in the coding region of the AT1 receptor gene were not significantly different between normal subjects and patients with aldosterone-producing adenomas as a group, nor between normal subjects and patients of either subgroup when compared with each other. 4. In those patients heterozygous in peripheral blood at the RFLP site, tumour DNA showed the same allelic pattern. 5. In patients with aldosterone-producing adenomas either responsive or unresponsive to the renin-angiotensin system, no differences were detected using SSCP analysis in the coding region of the AT1 receptor gene in peripheral blood or tumour tissue.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G N GillM H Simonian
Mar 1, 1987·Clinical and Experimental Pharmacology & Physiology·R D GordonS A Klemm
Dec 1, 1994·Kidney International·S A KlemmM Stowasser
Sep 1, 1994·Clinical Endocrinology·T FeltynowskiW Januszewicz
Dec 1, 1993·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·S A KlemmR D Gordon
May 16, 1994·Biochemical and Biophysical Research Communications·R TakayanagiH Nawata
May 1, 1993·Clinical and Experimental Pharmacology & Physiology·S KlemmR Gordon
Jul 1, 1993·Journal of the American Society of Nephrology : JASN·M D CookC S Wilcox

❮ Previous
Next ❯

Citations

May 17, 2001·Current Hypertension Reports·M Stowasser
Dec 24, 1998·Molecular and Cellular Endocrinology·Y KitamuraT Saruta
Oct 12, 2001·The Journal of Steroid Biochemistry and Molecular Biology·M Stowasser, R D Gordon
Aug 30, 2003·Trends in Endocrinology and Metabolism : TEM·Michael Stowasser, Richard D Gordon
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·R D Gordon, M Stowasser
Jul 29, 2000·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H Suzuki
Jul 1, 1997·Clinical and Experimental Hypertension : CHE·R D Gordon
May 14, 2011·Endocrinology and Metabolism Clinics of North America·Michael StowasserRichard D Gordon
Sep 19, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Michael Stowasser, Richard D Gordon
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·G OpocherF Mantero
Feb 24, 2004·Molecular Pharmacology·Jakob Lerche HansenDavid M Weiner
Sep 20, 2000·Journal of Hypertension·M Stowasser, R D Gordon
Sep 21, 2000·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·G J Laundy, J L Bidwell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical and Experimental Pharmacology & Physiology
D M BallantineR D Gordon
Trends in Endocrinology and Metabolism : TEM
R D Gordon, M Stowasser
© 2021 Meta ULC. All rights reserved