PCSK9 and triglyceride-rich lipoprotein metabolism

Journal of Biomedical Research
I DruceT C Ooi

Abstract

Pro-protein convertase subtilisin-kexin 9 (PCSK9) is known to affect low-density lipoprotein (LDL) metabolism, but there are indications from several lines of research that it may also influence the metabolism of other lipoproteins, especially triglyceride-rich lipoproteins (TRL). This review summarizes the current data on this possible role of PCSK9. A link between PCSK9 and TRL has been suggested through the demonstration of (1) a correlation between plasma PCSK9 and triglyceride (TG) levels in health and disease, (2) a correlation between plasma PCSK9 and markers of carbohydrate metabolism, which is closely related to TG metabolism, (3) an effect of TG-lowering fibrate therapy on plasma PCSK9 levels, (4) an effect of PCSK9 on postprandial lipemia, (5) an effect of PCSK9 on adipose tissue biology, (6) an effect of PCSK9 on apolipoprotein B production from the liver and intestines, (7) an effect of PCSK9 on receptors other than low density lipoprotein receptor (LDLR) that are involved in TRL metabolism, and (8) an effect of anti-PCSK9 therapy on serum TG levels. The underlying mechanisms are unclear but starting to emerge.

Citations

Mar 18, 2016·Atherosclerosis·Yajnavalka BanerjeeManfredi Rizzo
Jun 28, 2018·Journal of Lipid Research·Jean-Philippe Drouin-ChartierPatrick Couture
Dec 13, 2016·Circulation·Gerald F WattsP Hugh R Barrett
May 14, 2017·British Journal of Pharmacology·Ruth Andrew, Angelo A Izzo
Jul 5, 2017·The Journal of Clinical Endocrinology and Metabolism·Teik Chye OoiDonna F Vine
Jul 15, 2020·International Urology and Nephrology·Nutsiwat DidasNutjaree Jeenduang
Oct 9, 2020·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Olesya FedoryakMajambu Mbikay

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