PCSK9 is associated with mortality in patients with septic shock: data from the ALBIOS study.

Journal of Internal Medicine
A VecchiéALBIOS Biomarkers Study Investigators

Abstract

Pro-protein convertase subtilisin/kexin 9 (PCSK9) is a proenzyme primarily known to regulate low-density lipoprotein receptor re-uptake on hepatocytes. Whether PCSK9 can concurrently trigger inflammation or not remains unclear. Here, we investigated the potential association between circulating levels of PCSK9 and mortality in patients with severe sepsis or septic shock. Plasma PCSK9 levels at days 1, 2 and 7 were measured in 958 patients with severe sepsis or septic shock previously enrolled in the Albumin Italian Outcome Sepsis (ALBIOS) trial. Correlations between levels of PCSK9 and pentraxin 3 (PTX3), a biomarker of disease severity, were evaluated with ranked Spearman's coefficients. Cox proportional hazards models were used to assess the association of PCSK9 levels at day 1 with 28- and 90-day mortality. Median plasma PCSK9 levels were 278 [182-452] ng mL-1 on day 1. PCSK9 correlated positively with PTX3 at the three time-points, and patients with septic shock within the first quartile of PCSK9 showed higher levels of PTX3. Similar mortality rates were observed in patients with severe sepsis across PCSK9 quartiles. Patients with septic shock with lower PCSK9 levels on day 1 (within the first quartile) showed the highest 2...Continue Reading

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Citations

Aug 17, 2020·Journal of Clinical Medicine·Anne MerrelaarChristian Schoergenhofer
Jun 26, 2020·European Journal of Clinical Investigation·Aldo BonaventuraFabrizio Montecucco
Oct 31, 2020·Journal of Immunology Research·Yuan YuanZhi Chen
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Jun 27, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Dafne Jacome SanzMarko Pesu
Oct 10, 2021·Endocrine Reviews·Nabil G Seidah, Annik Prat

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