PCTR1 improves pulmonary edema fluid clearance through activating the sodium channel and lymphatic drainage in lipopolysaccharide-induced ARDS.

Journal of Cellular Physiology
Pu-Hong ZhangSheng-Wei Jin

Abstract

Acute respiratory distress syndrome (ARDS) is a lethal clinical syndrome characterized by damage of the epithelial barriers and accumulation of pulmonary edema fluid. Protectin conjugates in tissue regeneration 1 (PCTR1), an endogenously produced lipid mediator, are believed to exert anti-inflammatory and pro-resolution effects. PCTR1 (1 µg/kg) was injected at 8 hr after lipopolysaccharide (LPS; 14 mg/kg) administration, and the rate of pulmonary fluid clearance was measured in live rats at 1 hr after PCTR1 treatment. The primary type II alveolar epithelial cells were cultured with PCTR1 (10 nmol/ml) and LPS (1 μg/ml) for 8 hr. PCTR1 effectively improved pulmonary fluid clearance and ameliorated morphological damage and reduced inflammation of lung tissue, as well as improved the survival rate in the LPS-induced acute lung injury (ALI) model. Moreover, PCTR1 markedly increased sodium channel expression as well as Na, K-ATPase expression and activity in vivo and in vitro. In addition, PCTR1i also upregulated the expression of LYVE-1 in vivo. Besides that, BOC-2, HK7, and LY294002 blocked the promoted effect of PCTR1 on pulmonary fluid clearance. Taken together, PCTR1 upregulates sodium channels' expression via activating the ALX...Continue Reading

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Citations

Sep 5, 2020·Essays in Biochemistry·Nan Chiang, Charles N Serhan
Mar 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Nan ChiangCharles N Serhan
Mar 11, 2021·The American Journal of Pathology·Brian E SansburyMatthew Spite
Apr 30, 2021·Pharmacology & Therapeutics·Dipak PanigrahyKhosrow Kashfi
Jun 25, 2021·Frontiers in Pharmacology·Xinyu CuiHongyue Ma
Dec 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Ashley E ShayCharles N Serhan

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