journal cover

PD-1 blockade enhances the vaccination-induced immune response in glioma

JCI Insight

Jul 28, 2016

Joseph P AntoniosRobert M Prins

Abstract

DC vaccination with autologous tumor lysate has demonstrated promising results for the treatment of glioblastoma (GBM) in preclinical and clinical studies. While the vaccine appears capable of inducing T cell infiltration into tumors, the effectiveness of active vaccination in progressi...read more

Mentioned in this Paper

Pathologic Cytolysis
Biological Markers
Study
In Vivo
Immune Response
Biochemical Pathway
Immune Resistance
T-Lymphocyte
Combination Drug Therapy
Vaccines
21
14
1
61
Paper Details
References
  • References45
  • Citations14
12345
  • References45
  • Citations14
12

Similar Papers Found In These Feeds

Non-Small Cell Lung Cancer Recurrence

Glioblastoma Multiforme

Glioblastoma Multiforme (GBM) is a tumor that develops from astrocytes and oligodendrocytes. Here is the latest research on mechanisms that underlie GBM and associated therapeutic approaches.

Integrin Signalling

Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. Discover the latest research on integrin signalling here.

Immune Therapies In Cancer

Immunotherapy in cancer is used to help the immune system fight against invading cancer cells. It is used to slow the progression of the disease and prevent metastasis while enhancing the immune response. There are different types, including monoclonal antibodies and checkpoint inhibitors. Here is the latest research on immune therapies in cancer.

Immunologic Surveillance

Immunological surveillance occurs when T-cells detect and destroy virally infected or neoplastically transformed cells in the body. Discover the latest research on immunologic surveillance here.

Immunomodulating Agents

Immunomodulating agents are substances that stimulate or suppresse the immune system and may help the body combat againsts cancer, infection, or other diseases. Discover the latest research on immunomodulating agents here.

Glioma Cells

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cross-Priming

Cross-priming is the process whereby professional APC, mainly dendritic cells, prime t-cells by presenting antigens processed from proteins of other cells such as tumor cells or virus-infected cells. Discover the latest research on cross-priming here.

Tumor Vaccines

Tumor vaccines offer the potential for preventing cancer in high-risk individuals, preventing disease relapse after diagnosis and initial therapy, and shifting the balance of the host-tumor interaction to mitigate the progression of advanced cancers. Discover the latest research on tumor vaccines here.

© 2020 Meta ULC. All rights reserved

PD-1 blockade enhances the vaccination-induced immune response in glioma

JCI Insight

Jul 28, 2016

Joseph P AntoniosRobert M Prins

PMID: 27453950

DOI: 10.1172/jci.insight.87059

Abstract

DC vaccination with autologous tumor lysate has demonstrated promising results for the treatment of glioblastoma (GBM) in preclinical and clinical studies. While the vaccine appears capable of inducing T cell infiltration into tumors, the effectiveness of active vaccination in progressi...read more

Mentioned in this Paper

Pathologic Cytolysis
Biological Markers
Study
In Vivo
Immune Response
Biochemical Pathway
Immune Resistance
T-Lymphocyte
Combination Drug Therapy
Vaccines
21
14
1
61

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References45
  • Citations14
12345
  • References45
  • Citations14
12
/papers/pd-1-blockade-enhances-the-vaccination-induced/27453950