PD-1 deficiency enhances humoral immunity of malaria infection treatment vaccine

Infection and Immunity
Taiping LiuWenyue Xu

Abstract

Malaria infection treatment vaccine (ITV) is a promising strategy to induce homologous and heterologous protective immunity against the blood stage of the parasite. However, the underlying mechanism of protection remains largely unknown. Here, we found that a malaria-specific antibody (Ab) could mediate the protective immunity of ITV-immunized mice. Interestingly, PD-1 deficiency greatly elevated the levels of both malaria-specific total IgG and subclass IgG2a and enhanced the protective efficacy of ITV-immunized mice against the blood-stage challenge. A serum adoptive-transfer assay demonstrated that the increased Ab level contributed to the enhanced protective efficacy of the immunized PD-1-deficient mice. Further study showed that PD-1 deficiency could also promote the expansion of germinal center (GC) B cells and malaria parasite-specific TFH cells in the spleens of ITV-immunized mice. These results suggest that PD-1 deficiency improves the protective efficacy of ITV-immunized mice by promoting the generation of malaria parasite-specific Ab and the expansion of GC B cells. The results of this study provide new evidence to support the negative function of PD-1 on humoral immunity and will guide the design of a more effective...Continue Reading

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Citations

May 15, 2018·The Journal of Infectious Diseases·Chelsea L EdwardsChristian R Engwerda
Apr 27, 2019·Annals of the New York Academy of Sciences·Tijana Martinov, Brian T Fife
Jul 22, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tijana MartinovBrian T Fife
Apr 8, 2020·Frontiers in Public Health·Hongli GuanXiaohong Peng
Jun 25, 2018·Medical Microbiology and Immunology·Esaki M ShankarA P Dash
Dec 29, 2020·Frontiers in Cellular and Infection Microbiology·Chunmei CaiXiao Yu

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