PD-1 Expression in Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) and Large B-cell Richter Transformation (DLBCL-RT): A Characteristic Feature of DLBCL-RT and Potential Surrogate Marker for Clonal Relatedness

The American Journal of Surgical Pathology
Rong HeKaren L Rech

Abstract

Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a low-grade B-cell neoplasm and ∼2% to 9% patients develop an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (Richter transformation, DLBCL-RT). Programmed death-1 (PD-1) pathway plays a crucial role in tumor host immunity evasion and its blockade has emerged as an effective anti-cancer immunotherapy. PD-L1 and PD-1 expression has shown predictive value in anti-PD cancer immunotherapy; however, it has not been well documented in CLL/SLL and DLBCL-RT. We evaluated PD-1 and PD-L1 expression by immunohistochemistry in 39 CLL/SLL, 15 DLBCL-RT, and 26 other DLBCL. In CLL/SLL, neoplastic B-cell PD-1 expression was weak and restricted to prolymphocytes/paraimmunoblasts within proliferation centers (PCs) and accentuated PCs of all sizes. Neoplastic B-cell PD-1 expression was highly prevalent and demonstrated increased intensity in DLBCL-RT, but in contrast was only rarely seen in other DLBCL (12/15 vs. 1/26; P<0.0001). An excellent correlation (90% concordance) was observed between neoplastic B-cell PD-1 immunohistochemistry positivity and molecularly defined CLL/SLL clonal relatedness in DLBCL-RT. PD-L1 expression was observed on the neoplastic B ce...Continue Reading

References

Oct 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L E RobertsonM J Keating
Dec 4, 2004·Cancer·Apostolia-Maria Tsimberidou, Michael J Keating
Aug 2, 2005·The Cancer Journal·Karen W L YeeFrancis J Giles
Jul 5, 2006·The American Journal of Surgical Pathology·David M DorfmanGordon J Freeman
May 22, 2008·British Journal of Haematology·Davide RossiGianluca Gaidano
Jul 20, 2010·Immunological Reviews·Loise M FranciscoArlene H Sharpe
Sep 8, 2010·Seminars in Cancer Biology·Graham Packham, Freda Stevenson
May 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J AndorskyJohn M Timmerman
Aug 6, 2011·Blood·Freda K StevensonGraham Packham
Jan 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael R GreenMargaret A Shipp
Jun 5, 2012·The New England Journal of Medicine·Suzanne L TopalianMario Sznol
May 16, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin J ChenScott J Rodig
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Jun 4, 2013·The New England Journal of Medicine·Jedd D WolchokMario Sznol
Dec 24, 2013·Clinical Neuropathology·Anna Sophie BerghoffMatthias Preusser
Dec 9, 2014·The New England Journal of Medicine·Stephen M AnsellPhilippe Armand
Apr 22, 2015·The New England Journal of Medicine·Caroline RobertUNKNOWN KEYNOTE-006 investigators
Apr 22, 2015·The New England Journal of Medicine·Edward B GaronUNKNOWN KEYNOTE-001 Investigators
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 2, 2015·The Journal of Clinical Investigation·Lieping Chen, Xue Han
Sep 12, 2015·Cell·Sonja KleffelTobias Schatton
Oct 4, 2015·Biochimica Et Biophysica Acta·Yi XiaKen H Young
Dec 8, 2015·The New England Journal of Medicine·Andrew W RobertsJohn F Seymour

❮ Previous
Next ❯

Citations

Dec 7, 2018·Hematology·Wei Ding
Oct 20, 2018·Current Hematologic Malignancy Reports·Bei HuNilanjan Ghosh
Jan 18, 2019·International Journal of Hematologic Oncology·John N Allan, Richard R Furman
Jan 13, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen M Ansell
Nov 13, 2020·Journal of Immunology Research·John ApostolidisHani Al Hashmi
Dec 10, 2020·Journal of Immunology Research·Maansi Joshi, Stephen M Ansell
Feb 18, 2021·International Journal of Hematology·Susu Lu, Sha Zhao
Mar 30, 2021·Blood Reviews·Anna PetrackovaEva Kriegova
May 12, 2021·Blood Cancer Journal·Yucai WangWei Ding
Jun 28, 2021·Hematology/oncology Clinics of North America·Wei Ding
Aug 26, 2020·Current Cancer Drug Targets·Saba Hasan
Sep 2, 2021·Cancer Immunology, Immunotherapy : CII·Esteban Enrique EliasRomina Gamberale

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
Fluorescence
Assay
PCR
biopsies

Software Mentioned

Invivoscribe LymphoTrack IGHV SHM
JMP
R
Sequencher
DTComPair

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.