PD-1 Inhibition Achieves a Complete Metabolic Response in a Patient with Malignant Peripheral Nerve Sheath Tumor

Cancer Immunology Research
Lisa E DavisDaruka Mahadevan

Abstract

High-grade malignant peripheral nerve sheath tumors (MPNST) have a poor prognosis with limited responsiveness to systemic therapy. We document a case of a complete metabolic response to pembrolizumab monotherapy in metastatic disease. Tumor molecular profiling identified programmed-death ligand-1 (PD-L1) positivity. This characteristic provided a rationale for immune-checkpoint therapy. Treatment with pembrolizumab resulted in a complete metabolic response after four cycles of therapy. Patients with PD-L1-positive, metastatic MPNST may be candidates for immune-checkpoint therapy, which may produce a durable complete remission. Future study of anti-PD-1/PD-L1 therapy is warranted.

References

Jan 15, 2014·Annals of Diagnostic Pathology·Khin Thway, Cyril Fisher
Jan 29, 2014·The Oncologist·Mohamad FaridRobert G Maki
Mar 13, 2014·The Lancet Oncology·Ian JudsonUNKNOWN European Organisation and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A PostowJedd D Wolchok
Mar 11, 2015·Nature·Christina Twyman-Saint VictorAndy J Minn
Apr 4, 2015·Science·Padmanee Sharma, James P Allison
May 16, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amita PatnaikAnthony W Tolcher
Jan 30, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T ValentinC Chevreau
Jul 17, 2016·Medical Oncology·Semra PaydasGulfiliz Gonlusen
Sep 4, 2016·Surgical Oncology Clinics of North America·Aaron W JamesFritz C Eilber
Jan 4, 2017·Clinical Sarcoma Research·L PaoluzziG Rosen
Jun 13, 2017·World Neurosurgery·Ryuya Yamanaka, Azusa Hayano
Nov 21, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Robin VeenstraJudith Vmg Bovée
Sep 8, 2018·Frontiers in Oncology·Henry T Marshall, Mustafa B A Djamgoz
Oct 6, 2018·Trends in Biochemical Sciences·Jinfang ZhangWenyi Wei

❮ Previous
Next ❯

Citations

Mar 1, 2021·Current Treatment Options in Oncology·Ayesha HassanAmanda Parkes
Jul 6, 2021·European Journal of Histochemistry : EJH·Kazuhiko HashimotoMasao Akagi
Aug 28, 2021·International Journal of Molecular Sciences·Teddy MohamadJean-Philippe Brosseau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Japanese Journal of Clinical Oncology
Shuji Kayano, Akira Kawai
International Journal of Radiation Oncology, Biology, Physics
W W WongL L Gunderson
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Lei ZhengYan Gao
Journal of Hematology & Oncology
Georgia J B McCaughanVivek A Bhadri
© 2021 Meta ULC. All rights reserved