PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications

Human Pathology
Claudio LuchiniAldo Scarpa

Abstract

Undifferentiated carcinoma with osteoclast-like giant cells (UCOGC), a variant of pancreatic ductal adenocarcinoma (PDAC), has a striking genetic similarity to PDAC but a significantly improved overall survival. We hypothesize that this difference could be due to the immune response to the tumor, and as such, we investigated the expression of PD-1, PD-L1, and CD163 in a series of UCOGC. To this aim, 27 pancreatic UCOGCs (11 pure and 16 PDAC-associated), 5 extrapancreatic tumors with osteoclast-like giant cells and 10 pancreatic anaplastic carcinomas were immunostained using antibodies against PD-1, PD-L1, and CD163. In pancreatic UCOGCs, PD-L1 was expressed in neoplastic cells of 17 (63%) of 27 cases, more often in cases with an associated PDAC (P = .04). Expression of PD-L1 was associated with poor prognosis, confirmed by multivariate analysis: patients with PD-L1-positive UCOGCs had a risk of all-cause mortality that was 3 times higher than did patients with PD-L1-negative UCOGCs (hazard ratio, 3.397; 95% confidence interval, 1.023-18.375; P = .034). PD-L1 expression on tumor cells was also associated with aberrant P53 expression (P = .035). PD-1 was expressed on rare lymphocytes in 12 UCOGCs (44.4%), mainly located at the tu...Continue Reading

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Citations

May 27, 2020·World Journal of Surgical Oncology·Toshihisa KimuraTakanori Goi
Jul 15, 2020·Virchows Archiv : an International Journal of Pathology·Paola MattioloClaudio Luchini
Dec 4, 2020·International Journal of Molecular Sciences·Chiara BazzichettoMichele Milella
Jan 16, 2021·Virchows Archiv : an International Journal of Pathology·Claudio Luchini
Jan 16, 2021·Journal of Gastrointestinal Cancer·Ayoub KharkhachTijani El Harroudi
Feb 23, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Jin LiTingbo Liang
Mar 23, 2021·Frontiers in Oncology·Pieter DemetterLaurine Verset
Mar 6, 2021·Journal of the National Comprehensive Cancer Network : JNCCN·Robert J BesawBenjamin L Schlechter
Nov 13, 2020·Pathologica·Claudio LuchiniGiuseppe Zamboni
Nov 13, 2020·Pathologica·Claudio LuchiniAldo Scarpa
Dec 1, 2021·Expert Opinion on Therapeutic Targets·Nicola SilvestrisConcetta Saponaro
Dec 23, 2021·Expert Opinion on Therapeutic Targets·Paola MattioloClaudio Luchini

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