PD-1/PD-L1 Based Combinational Cancer Therapy: Icing on the Cake

Frontiers in Pharmacology
Jian-Ye ZhangLi-Wu Fu

Abstract

Cancer has been a major global health problem due to its high morbidity and mortality. While many chemotherapy agents have been studied and applied in clinical trials or in clinic, their application is limited due to its toxic side effects and poor tolerability. Monoclonal antibodies specific to the PD-1 and PD-L1 immune checkpoints have been approved for the treatment of various tumors. However, the application of PD-1/PD-L1 inhibitors remains suboptimal and thus another strategy comes in to our sight involving the combination of checkpoint inhibitors with other agents, enhancing the therapeutic efficacy. Various novel promising approaches are now in clinical trials, just as icing on the cake. This review summarizes relevant investigations on combinatorial therapeutics based on PD-1/PD-L1 inhibition.

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Citations

Aug 20, 2020·Expert Opinion on Biological Therapy·Malgorzata Czystowska-Kuzmicz, Theresa L Whiteside
Oct 20, 2020·Frontiers in Oncology·Chaoyue SuJianye Zhang
Sep 2, 2020·Computational Biology and Chemistry·Christian Bailly, Gérard Vergoten
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Mar 7, 2021·International Journal of Molecular Sciences·Shang-Hung ChenJang-Yang Chang
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Sep 10, 2021·Molecular Cancer·Wenxiao JiangXueqiong Zhu
Feb 8, 2022·Human Vaccines & Immunotherapeutics·Arne BillmeierMustafa Diken

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Methods Mentioned

BETA
gene knockout

Clinical Trials Mentioned

NCT02374242
NCT02500797
NCT02572167
NCT02329847
NCT01024231
NCT01927419
NCT01844505
NCT02523469
NCT01928394
NCT02231749

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