Pd-Catalyzed Cross-Coupling of Terminal Alkynes with Chromium(0) Fischer Carbene Complexes

Organic Letters
Kang WangJianbo Wang

Abstract

Alkyl chromium(0) carbene complexes typically undergo cycloadditions with alkynes to afford carbo- or heterocyclic compounds. In the presence of Pd catalyst, it is demonstrated that a traditional cycloaddition pathway is completely altered: instead of cycloaddition, oxidative cross-coupling reaction of alkyl chromium(0) carbene complexes with terminal alkynes occurs. The coupling reaction exhibits excellent functional group tolerance and good efficiency.

References

Jul 18, 2001·Journal of the American Chemical Society·M A SierraM Gómez-Gallego
May 13, 2004·Chemical Reviews·José BarluengaMiguel Tomás
Oct 19, 2004·Chemical Communications : Chem Comm·Liang Chen, Chao-Jun Li
Jan 19, 2005·Accounts of Chemical Research·Mar Gómez-GallegoMiguel A Sierra
Oct 3, 2008·Chemical Communications : Chem Comm·Miguel A SierraFernando P Cossío
Dec 5, 2008·Chemistry : a European Journal·Marta L LageMiguel A Sierra
Aug 1, 2009·Chemical Reviews·Karl Heinz Dötz, Joachim Stendel
Jun 11, 2010·The Journal of Organic Chemistry·Chunrui WuWilliam D Wulff
Sep 14, 2010·Chemical Communications : Chem Comm·Manuel Ángel Fernández-RodríguezEnrique Aguilar
Apr 27, 2011·Accounts of Chemical Research·Israel FernándezMiguel A Sierra
Jul 26, 2011·Chemical Society Reviews·Zhihui Shao, Hongbin Zhang
Jun 7, 2012·Organic Letters·Lara VillarinoJosé L Mascareñas
Jan 8, 2013·The Journal of Organic Chemistry·Gong M ChuMiguel A Sierra
Jun 25, 2013·Chemical Reviews·Rafael Chinchilla, Carmen Nájera
Oct 19, 2013·The Journal of Organic Chemistry·Zhenxing Liu, Jianbo Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.