Pd-catalyzed domino carbonylative-decarboxylative allylation: an easy and selective monoallylation of ketones

Chemical Communications : Chem Comm
Steven GiboulotGiovanni Poli

Abstract

In the presence of an allyl alcohol, α-chloroacetophenones undergo an allyloxycarbonylation reaction followed by in situ decarboxylative allylation to selectively afford the corresponding monoallylated ketones via a Pd-catalyzed domino sequence. The scope of the reaction was extended to substituted α-chloroacetophenones as well as various allyl alcohols.

References

Dec 21, 2002·The Journal of Organic Chemistry·Giovanni Poli, Giuliano Giambastiani
Apr 16, 2003·Accounts of Chemical Research·Darcy A Culkin, John F Hartwig
Jun 17, 2010·Journal of the American Chemical Society·Barry M TrostAndreas K Buckl
Jan 18, 2011·Chemical Reviews·Jimmie D WeaverJon A Tunge

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Citations

Jun 7, 2014·Chemistry : a European Journal·Lutz F TietzeBernd Waldecker
Feb 14, 2013·Angewandte Chemie·Lutz F TietzeDietmar Stalke
Oct 3, 2018·Organic & Biomolecular Chemistry·Ziling Ma, Yuanhua Wang
May 8, 2013·Chemistry : a European Journal·Lutz F TietzeSven Heidemann
Jun 14, 2018·Organic Letters·Yang LiuGiovanni Poli
Apr 10, 2018·Organic Letters·Fares RoudeslyGiovanni Poli
Jan 29, 2013·The Journal of Organic Chemistry·Benoit WahlMathieu Sauthier

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