Pd-Catalyzed reductive heck reaction of olefins with aryl bromides for Csp2 -Csp3 bond formation

Chemical Communications : Chem Comm
Liqun JinXinquan Hu

Abstract

We developed a Pd-catalyzed intermolecular reductive Heck reaction to construct Csp2-Csp3 bonds between aryl bromides and olefins. Various styrene derivatives, acyclic and cyclic alkenes, were well tolerated to couple with varied aryl bromides in linear selectivity. Kinetic and deuterium labeling experiments suggested that i-PrOH provides a hydride through β-H elimination.

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Citations

Mar 12, 2019·Chemical Communications : Chem Comm·Yangyang HouNa Wu
Mar 27, 2019·Chemical Communications : Chem Comm·Jie CuiHui Liu
Feb 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·K Michał PietrusiewiczOleg M Demchuk
Aug 17, 2019·Chemical Communications : Chem Comm·Qixue QinNing Jiao
Apr 19, 2019·Chemical Science·Julia NguyenGojko Lalic
Sep 16, 2020·Nanomedicine : Nanotechnology, Biology, and Medicine·Mahsa KianiThomas J Webster
Feb 4, 2021·Chemical Communications : Chem Comm·Ke WuXinquan Hu
Nov 3, 2021·Angewandte Chemie·Anne K RavnTroels Skrydstrup

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Methods Mentioned

BETA
column chromatography

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