Pd-Catalyzed Regioselective Mono-Arylation: Quinazolinone as the Inherent Directing Group for C(sp2 )-H Activation

The Journal of Organic Chemistry
Dnyaneshwar N GaradSantosh B Mhaske

Abstract

The Pd-catalyzed quinazolinone-directed regioselective monoarylation of aromatic rings by C-H bond activation is developed. A broad substrate scope is demonstrated for both quinazolinone as well as diaryliodonium triflates. The use of a base was found to be crucial for this transformation, unlike for the known nitrogen-directed arylations. All of the novel quinazolinones of biological interest were synthesized by using the operationally simple Pd(II)-catalyzed arylation reaction.

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Citations

Jul 7, 2017·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Liyao Zheng, Ruimao Hua
Sep 7, 2017·Chemical Communications : Chem Comm·Jae Bin LeeSung You Hong
Jan 14, 2020·Chemical Communications : Chem Comm·Amol B VivekiSantosh B Mhaske
May 30, 2020·Organic & Biomolecular Chemistry·Prasanjit GhoshSajal Das
Mar 10, 2018·The Journal of Organic Chemistry·Pratheepkumar AnnamalaiShih-Ching Chuang
Aug 29, 2017·The Journal of Organic Chemistry·Dnyaneshwar N Garad, Santosh B Mhaske
Jan 29, 2019·The Journal of Organic Chemistry·Rajendra S RohokaleChepuri V Ramana

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