Pd-Catalyzed Remote Meta-C-H Functionalization of Phenylacetic Acids Using a Pyridine Template

Organic Letters
Zhong JinJin-Quan Yu

Abstract

An effective pyridine based U-shaped template has been developed to enable a diverse range of meta-C-H functionalizations of phenylacetic acid scaffolds. This new template has extended the reaction scope to cross-coupling with ArBF3K as well as iodination using 1,3-diiodo-5,5-dimethylhydantoin as the iodination reagent.

References

Mar 20, 2009·Journal of the American Chemical Society·Yang-Hui ZhangJin-Quan Yu
Mar 21, 2009·Science·Robert J Phipps, Matthew J Gaunt
Oct 23, 2010·Angewandte Chemie·Hung A DuongMatthew J Gaunt
Nov 4, 2011·Journal of the American Chemical Society·Ourida SaidiChristopher G Frost
Jun 29, 2012·Nature·Dasheng LeowJin-Quan Yu
Mar 29, 2013·Journal of the American Chemical Society·Nora Hofmann, Lutz Ackermann
Apr 26, 2013·Journal of the American Chemical Society·Hui-Xiong DaiJin-Quan Yu
Nov 19, 2013·Journal of the American Chemical Society·Li WanJin-Quan Yu
Dec 12, 2013·Journal of the American Chemical Society·Sunggi LeeKian L Tan
Mar 14, 2014·Nature·Ri-Yuan TangJin-Quan Yu
Jul 10, 2014·Journal of the American Chemical Society·Guoqiang YangJin-Quan Yu
Mar 11, 2015·Nature·Xiao-Chen WangJin-Quan Yu
Apr 25, 2015·Journal of the American Chemical Society·Zhe DongGuangbin Dong
Aug 20, 2015·Angewandte Chemie·Christopher J TeskeyMichael F Greaney
Aug 28, 2015·Journal of the American Chemical Society·Peng-Xiang ShenJin-Quan Yu
Dec 23, 2015·Journal of the American Chemical Society·Ranjana Bisht, Buddhadeb Chattopadhyay
Jan 28, 2016·Nature Communications·Shangda LiGang Li
May 5, 2016·Chemical Communications : Chem Comm·Jian HanYingsheng Zhao
May 18, 2016·Journal of the American Chemical Society·Zhoulong FanAo Zhang
Jul 8, 2016·Journal of the American Chemical Society·Peng WangJin-Quan Yu
Oct 8, 2016·Journal of the American Chemical Society·Peng WangJin-Quan Yu
Feb 17, 2017·Angewandte Chemie·Sukdev BagDebabrata Maiti

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Citations

Apr 28, 2018·Angewandte Chemie·Ramasamy JayarajanDebabrata Maiti
Aug 30, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Houguang Jeremy ChenPak-Hing Leung
Nov 30, 2018·Angewandte Chemie·Aniruddha DeyDebabrata Maiti

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