Pd-Ir Core-Shell Nanocubes: A Type of Highly Efficient and Versatile Peroxidase Mimic

ACS Nano
Xiaohu XiaHaihang Ye

Abstract

Peroxidase mimics with dimensions on the nanoscale have received great interest as emerging artificial enzymes for biomedicine and environmental protection. While a variety of peroxidase mimics have been actively developed recently, limited progress has been made toward improving their catalytic efficiency. In this study, we report a type of highly efficient peroxidase mimic that was engineered by depositing Ir atoms as ultrathin skins (a few atomic layers) on Pd nanocubes (i.e., Pd-Ir cubes). The Pd-Ir cubes exhibited significantly enhanced efficiency, with catalytic constants more than 20- and 400-fold higher than those of the initial Pd cubes and horseradish peroxidase (HRP), respectively. As a proof-of-concept demonstration, the Pd-Ir cubes were applied to the colorimetric enzyme-linked immunosorbent assay (ELISA) of human prostate surface antigen (PSA) with a detection limit of 0.67 pg/mL, which is ∼110-fold lower than that of the conventional HRP-based ELISA using the same set of antibodies and the same procedure.

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Citations

Jul 2, 2016·Chemical Reviews·Kyle D GilroyYounan Xia
Aug 10, 2016·ACS Applied Materials & Interfaces·Anjani P Nagvenkar, Aharon Gedanken
Jul 18, 2016·Biosensors & Bioelectronics·Xiangmin MiaoDik-Lung Ma
Apr 12, 2016·Chemistry : a European Journal·Evelyn KuahZhiqiang Gao
Feb 28, 2017·Analytical Chemistry·Zhuangqiang GaoXiaohu Xia
Nov 3, 2017·Chemical Communications : Chem Comm·Shazia MumtazIrshad Hussain
Nov 9, 2017·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Gao-Juan CaoJun-Jie Yin
Aug 28, 2019·Nanoscale·Michelle MuzzioShouheng Sun
Sep 4, 2019·Nature Nanotechnology·Colleen N LoynachanMolly M Stevens
Apr 14, 2020·Chembiochem : a European Journal of Chemical Biology·Zheng XiXiaohu Xia
Nov 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haihang Ye, Xiaohu Xia
Nov 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·G VinothkumarK Suresh Babu
Mar 2, 2019·Nanomaterials·Lin LiuNing Xia
Apr 1, 2020·Chembiochem : a European Journal of Chemical Biology·Yingxu ShangBaoquan Ding
Dec 12, 2020·Chemical Society Reviews·Lei JiaoChengzhou Zhu
Feb 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yuzhen LiYan-Yan Song
Dec 11, 2019·Nano Letters·Zheng XiXiaohu Xia
Nov 15, 2020·Chemical Communications : Chem Comm·Zhiyuan WeiXiaohu Xia
Jan 13, 2021·Sensors·Elicia L S WongEdith Chow

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