PD-L1 expressing circulating tumour cells in head and neck cancers

BMC Cancer
Arutha KulasingheChamindie Punyadeera

Abstract

Blockade of the PD-1/PD-L1 immune checkpoint pathway is emerging as a promising immunotherapeutic approach for the management and treatment of head and neck cancer patients who do not respond to 1st/2nd line therapy. However, as checkpoint inhibitors are cost intensive, identifying patients who would most likely benefit from anti PD-L1 therapy is required. Developing a non-invasive technique would be of major benefit to the patient and to the health care system. We report the case of a 56 year old man affected by a supraglottic squamous cell carcinoma (SCC). A CT scan showed a 20 mm right jugulodigastric node and suspicious lung lesions. The lung lesion was biopsied and confirmed to be consistent with SCC. The patient was offered palliative chemotherapy. At the time of presentation, a blood sample was taken for circulating tumour cell (CTC) analysis. The dissemination of cancer was confirmed by the detection of CTCs in the peripheral blood of the patient, measured by the CellSearch System (Janssen Diagnostics). Using marker-independent, low-shear spiral microfluidic technology combined with immunocytochemistry, CTC clusters were found in this patient at the same time point, expressing PD-L1. This report highlights the potential...Continue Reading

References

May 15, 2002·International Journal of Radiation Oncology, Biology, Physics·Avraham Eisbruch
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Nov 7, 2012·Cancer Metastasis Reviews·François-Clément BidardJean-Yves Pierga
Aug 21, 2013·Lab on a Chip·Majid Ebrahimi WarkianiJongyoon Han
May 14, 2014·Oral Oncology·Dan P Zandberg, Scott E Strome
Aug 12, 2014·International Journal of Cancer. Journal International Du Cancer·Arutha KulasingheChamindie Punyadeera
Jan 27, 2015·Current Opinion in Immunology·Daniel Sanghoon Shin, Antoni Ribas
Jun 22, 2015·Molecular Oncology·Martine MazelCatherine Alix-Panabières
Aug 20, 2015·Journal for Immunotherapy of Cancer·Leila KhojaAnthony M Joshua
Dec 4, 2015·Expert Review of Molecular Diagnostics·Henri SchmidtChamindie Punyadeera
Dec 19, 2015·Nature Protocols·Majid Ebrahimi WarkianiChwee Teck Lim
Mar 13, 2016·Cancer Discovery·Catherine Alix-Panabières, Klaus Pantel
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Sam H AuMehmet Toner
Aug 16, 2016·Oncotarget·Arutha KulasingheChamindie Punyadeera
Sep 23, 2016·Oncotarget·Arutha KulasingheChamindie Punyadeera
Oct 1, 2016·Oral Oncology·Henri SchmidtChamindie Punyadeera
Feb 16, 2017·Scientific Reports·Arutha KulasingheChamindie Punyadeera

❮ Previous
Next ❯

Citations

Sep 11, 2018·Expert Review of Molecular Diagnostics·Ingeborg Tinhofer, Stephanie Staudte
Jan 18, 2018·Scientific Reports·Arutha KulasingheChamindie Punyadeera
Feb 15, 2019·Expert Review of Molecular Diagnostics·Vivian Weiwen XueWilliam Chi Shing Cho
Nov 5, 2019·Expert Review of Molecular Diagnostics·Arutha KulasingheChamindie Punyadeera
Nov 15, 2018·Micromachines·Arutha KulasingheMajid Ebrahimi Warkiani
Aug 30, 2018·Frontiers in Oncology·Joanna KapelerisChamindie Punyadeera
Jul 16, 2019·Expert Review of Molecular Diagnostics·Marianna GalloNicola Normanno
Jan 24, 2020·Journal of Clinical Medicine·Qingyang XiaoIsabel Barragán
Feb 1, 2018·Therapeutic Advances in Medical Oncology·Galatea KallergiAthanasios Kotsakis
Dec 20, 2018·Cancer Medicine·Arutha KulasingheChamindie Punyadeera
Nov 5, 2020·Journal of Cellular Physiology·Hamidreza Aboulkheyr EsMajid E Warkiani
Nov 4, 2020·Expert Review of Molecular Diagnostics·Sayuri HerathArutha Kulasinghe
Nov 7, 2020·Technology in Cancer Research & Treatment·Muhammed A BakhrebahHani Choudhry
Apr 9, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Karima OuallaNawfel Mellas
Jun 5, 2021·Lab on a Chip·K PatersonM Zagnoni
Dec 29, 2020·International Journal of Oral and Maxillofacial Surgery·B M FisherM D Batstone

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
X-ray
chip

Software Mentioned

CellSearch

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.