PD-L1 Expression in Extramammary Paget Disease: A Case Series.

The American Journal of Dermatopathology
Mark R FowlerPaul B Googe

Abstract

The PD-1/PD-L1 pathway plays a critical role in the physiologic inhibition and modulation of the immune response in normal tissue. Many tumors evade immune detection and response by upregulating PD-L1 expression. Humanized monoclonal PD-1 and PD-L1 antibodies have proven as both tolerable and effective treatment in many neoplasms. Extramammary Paget disease (EMPD) is a deformative and debilitating cutaneous malignancy in which definitive treatment options are limited with high recurrence rates after surgical excision. To the best of our knowledge, there is little published information regarding EMPD and PD-L1 expression. We evaluated 18 EMPD surgical pathology cases for tumor cell and tumor-associated inflammatory (TAI) cell PD-L1 expression. We identified PD-L1 tumor cell expression in 3 (17%) of the cases: 2 of 4 invasive cases (50%) and 1 of 14 (7%) noninvasive cases. One invasive case had lymph nodal metastasis with PD-L1 tumor cell expression. The host inflammatory response intensity and PD-L1 expression were variable in cases negative for tumor cell PD-L1 expression; however, a marked inflammatory response and TAI PD-L1 expression were present in all cases positive for tumor cell PD-L1 expression. In conclusion, 1 in 14 (...Continue Reading

References

Apr 11, 2000·The American Journal of Surgical Pathology·J A Brainard, W R Hart
May 19, 2005·The American Journal of Dermatopathology·Joseph H WillmanJames E Fitzpatrick
Dec 3, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ruthy Shaco-LevyStanley J Robboy
Jan 7, 2010·The American Journal of Dermatopathology·John PerrottoIftikhar Ahmed
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerSuzanne L Topalian
Sep 20, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Yasuhiro ItoHajime Iizuka
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Aug 5, 2014·Clinical Medicine Insights. Oncology·Derek IsrowOrlando Silva
Aug 1, 2015·Nature Reviews. Drug Discovery·Kathleen M MahoneyGordon J Freeman
Oct 21, 2016·The American Journal of Dermatopathology·Anastasia M KonstantinovaDmitry V Kazakov
Mar 14, 2016·Critical Reviews in Oncology/hematology·M van der LindenJ A de Hullu
May 21, 2016·Journal of Lower Genital Tract Disease·John Livingston Powell
Dec 21, 2016·Rare Tumors·Leslie PadrnosThorvardur R Halfdanarson
Jan 27, 2017·Gynecologic Oncology Reports·Cherry O OnaiwuKathleen M Schmeler
Apr 12, 2017·Advances in Anatomic Pathology·Eric J YangTeri A Longacre
Jun 27, 2018·Cancer Immunology, Immunotherapy : CII·Georgia KarpathiouMichel Peoc'h
Jan 25, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Giulia MantovaniGiorgia Garganese
Apr 7, 2019·Cancer Immunology, Immunotherapy : CII·Lucie DuvergerMaxime Battistella
Jul 13, 2019·Journal of Cancer Research and Clinical Oncology·Giorgia GarganeseGian Franco Zannoni

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