PD-L1 Expression in Glioblastoma, the Clinical and Prognostic Significance: A Systematic Literature Review and Meta-Analysis

Frontiers in Oncology
Chengcheng HaoWen G Jiang

Abstract

Background: The clinical and prognostic value of programmed death-ligand 1, PD-L1, in glioblastoma remains controversial. The present study aimed to identify the expression of PD-L1 for its prognostic value in glioblastoma. Methods: A comprehensive literature search was performed using the PubMed and CNKI databases. The overall survival (OS) and disease-free survival (DFS) of GBM was analyzed based on Hazard ratios (HRs) and 95% confidence intervals (CIs). Furthermore, Odds ratios (ORs) and 95% CIs were summarized for clinicopathological parameters. The statistical analysis was using RevMan 5.3 software. Results: The meta-analysis was performed by using total nine studies including 806 patients who had glioblastoma. The pooled results indicated that PD-L1 expression in tumor tissues was significantly related to a poor OS (HR = 1.63, 95%CI: 1.19-2.24, P = 0.003, random effects model) with heterogeneity (I2 = 51%). In subgroup analyses, PD-L1 positivity was significantly associated with a worse OS for patients of American and Asian regions, but not for those of European regions. Moreover, PD-L1 expression implied a trend toward the mutation status of the IDH1 gene [coding the Isocitrate Dehydrogenase (NADP(+))-1 protein] (HR = 9....Continue Reading

References

Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michal MarzecMariusz A Wasik
Dec 5, 2009·Ai zheng = Aizheng = Chinese journal of cancer·Xiao-Ling ChenXian-Yuan Wang
Jul 10, 2010·The Lancet Oncology·Nanne K KloosterhofMartin J van den Bent
Dec 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert M PrinsLinda M Liau
Jan 1, 2008·Clinical Medicine. Oncology·Ricardo J KomotarE Sander Connolly
Oct 18, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leslie L MuldoonEdward A Neuwelt
Dec 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroko Ohgaki, Paul Kleihues
Mar 7, 2013·International Journal of Radiation Oncology, Biology, Physics·Jing ZengMichael Lim
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Fang WeiJames L Riley
Aug 30, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yawei LiuShohreh Issazadeh-Navikas
Nov 30, 2013·Pharmaceuticals·Yulian P RamirezAlonzo H Ross
Mar 22, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kurt A SchalperDavid L Rimm
Apr 3, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Derek A WainwrightMaciej S Lesniak
Oct 31, 2014·Neuro-oncology·Anna Sophie BerghoffWolfgang Wick
Nov 16, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter E FecciJohn H Sampson
Mar 4, 2015·Drug Design, Development and Therapy·Yi QingDong Wang
Apr 11, 2015·Cancer Cell·Suzanne L TopalianDrew M Pardoll
May 7, 2015·Pharmacology & Therapeutics·Constantinos Alifieris, Dimitrios T Trafalis
Aug 28, 2015·Expert Review of Anticancer Therapy·Elnaz FaghfuriMohammad Abdollahi
Sep 2, 2015·Neuro-oncology·Edjah K NduomAmy B Heimberger
Sep 2, 2015·The Journal of Clinical Investigation·Lieping Chen, Xue Han
Jul 3, 2016·Neuro-oncology·Sarah T GarberAmy B Heimberger
Aug 24, 2016·Genes & Cancer·Katherine M MoxleyMagdalena Bieniasz
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Feb 9, 2017·Oncotarget·Dieter Henrik HeilandOliver Schnell
Mar 11, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ricky ChenHoward Colman
Apr 9, 2017·Journal of Hematology & Oncology·Song XueJinming Yu

❮ Previous
Next ❯

Citations

Aug 31, 2020·Expert Review of Clinical Pharmacology·Patrick C GedeonJohn H Sampson
Mar 7, 2021·Brain Sciences·Jakub LitakCezary Grochowski
Apr 4, 2021·Journal of Clinical Medicine·Pasquale PersicoMatteo Simonelli
May 9, 2021·Journal of Cancer Research and Clinical Oncology·Dorothee HölzlTheo F J Kraus
Jun 10, 2021·The European Journal of Neuroscience·Vimal Patel, Jigar Shah

❮ Previous
Next ❯

Clinical Trials Mentioned

NCT02336165
NCT01375842

Software Mentioned

STATA
Review Manager
PRISM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
A WangG T Liu
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
X NiJ Suo
© 2021 Meta ULC. All rights reserved