PD-L1 expression in Xp11.2 translocation renal cell carcinoma: Indicator of tumor aggressiveness

Scientific Reports
Kun ChangDingwei Ye

Abstract

Programmed death ligand-1 (PD-L1), a promising antitumor target, has proven clinical value against many malignancies. However, the PD-L1 content of Xp11.2 translocation renal cell carcinoma (Xp11.2 RCC) and its correlation with clinical outcomes remain unclear. This study aimed to investigate PD-L1 expression in Xp11.2 RCC and to assess its prognostic value. Formalin-fixed paraffin-embedded specimens from 36 adult patients that were histologically confirmed (by fluorescence in situ hybridization) were subjected to immunohistochemical analysis. Of the 36 Xp11.2 RCC patients, 9 (25.0%) had tumors with positive PD-L1 expression and 27 (75.0%) had tumors with negative PD-L1 expression. Positive PD-L1 expression correlated with advanced tumor stage (P = 0.001), regional lymph node metastasis (P < 0.001), and distant metastasis (P < 0.001). A multivariate analysis identified positive PD-L1 expression was an independent adverse prognostic factor for both progression free survival (hazard ratio: 3.7, P = 0.018) and overall survival (hazard ratio: 4.5, P = 0.034). The median PFS and OS for the whole cohort were 13.0 months (95% confidence interval [CI], 9.4-16.6 months) and 36.0 months (95% CI, 23.9-48.1 months), respectively. Our findi...Continue Reading

References

Aug 19, 2004·The American Journal of Surgical Pathology·Elisabeth BruderHolger Moch
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·R Houston ThompsonEugene D Kwon
Jan 31, 2006·European Urology·Antonio Lopez-BeltranZiya Kirkali
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·R Houston ThompsonEugene D Kwon
Jun 21, 2007·American Journal of Clinical Pathology·Paul N MeyerMaria M Picken
Aug 2, 2007·The American Journal of Surgical Pathology·Pedram ArganiMarc Ladanyi
Dec 17, 2010·International Journal of Clinical Oncology·Kazuyuki NumakuraTomonori Habuchi
Dec 6, 2011·Immunology Letters·Xavier FrigolaEugene D Kwon
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Aug 13, 2014·Nature Reviews. Urology·Jaimin R Bhatt, Antonio Finelli
Sep 7, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T K ChoueiriS Signoretti
Dec 3, 2014·Trends in Molecular Medicine·Kim C OhaegbulamXingxing Zang
Dec 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Toni K ChoueiriRobert J Motzer
Apr 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott N GettingerJulie R Brahmer
Jul 2, 2015·BMC Urology·Linfeng XuHongqian Guo
Sep 9, 2015·JAMA : the Journal of the American Medical Association·James P Allison
Sep 26, 2015·The New England Journal of Medicine·Robert J MotzerUNKNOWN CheckMate 025 Investigators
Jan 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David F McDermottThomas Powles
Aug 31, 2016·OncoTargets and Therapy·Xin WangJinming Yu

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.