PD-L1 expression is associated with ALK positivity and STAT3 activation, but not outcome in patients with systemic anaplastic large cell lymphoma.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Jing ShenJie Xu

Abstract

The programmed cell death 1 (PD-1) pathway is a recently recognized mechanism of tumor immune evasion. In this study, programmed cell death ligand 1 (PD-L1) expression was evaluated in 95 patients with systemic anaplastic large cell lymphoma: 45 ALK+ and 50 ALK-. ALK+ anaplastic large cell lymphoma was more often positive for PD-L1 than ALK- anaplastic large cell lymphoma (76% vs 42%, p = 0.002). ALK- anaplastic large cell lymphoma showed a strong correlation between PD-L1 expression and STAT3 activation (measured by pSTAT3Tyr705) (r = 0.8, p < 0.0001). In contrast, the PD-L1/pSTAT3 correlation was weaker in ALK+ anaplastic large cell lymphoma (r = 0.4, p = 0.08). In ALK- anaplastic large cell lymphoma, the PD-L1+ subgroup was more often EMA positive (69% vs 20%, p = 0.02) and tended to be less often CD2+ (50% vs 83%, p = 0.059). In ALK+ anaplastic large cell lymphoma, PD-L1 was not associated with pathologic features (all p > 0.05). Negative ALK status and high IPI score (≥3) were associated with shorter overall survival (p = 0.009 and p = 0.0005, respectively). Overall survival was not different between patients with PD-L1+ vs PD-L1- anaplastic large cell lymphoma (p = 0.44), regardless of ALK status and International Prognos...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
May 17, 2005·Nature Medicine·Roberto ChiarleGiorgio Inghirami
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Junzo HamanishiShingo Fujii
Apr 17, 2007·Current Opinion in Immunology·Mary E KeirArlene H Sharpe
May 27, 2008·Nature Reviews. Immunology·Weiping Zou, Lieping Chen
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie VoseUNKNOWN International T-Cell Lymphoma Project
Dec 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Michal MarzecMariusz A Wasik
Apr 28, 2011·Cancer·Jules GadiotChristian Blank
May 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J AndorskyJohn M Timmerman
Oct 10, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David SibonHervé Tilly
May 16, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin J ChenScott J Rodig
Dec 9, 2014·The New England Journal of Medicine·Stephen M AnsellPhilippe Armand
Apr 16, 2015·Cancer Cell·Ramona CrescenzoUNKNOWN European T-Cell Lymphoma Study Group, T-Cell Project: Prospective Collection of Data in Patients with Peripheral T-Cell Lymp
Jan 12, 2016·The American Journal of Surgical Pathology·Jie XuScott J Rodig
Apr 14, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Margaretha G M RoemerMargaret A Shipp
Jun 30, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philippe ArmandCraig H Moskowitz
Oct 18, 2016·Annals of Internal Medicine·Holger HebartWilhelm Woessmann
Oct 25, 2016·The American Journal of Surgical Pathology·Zhihong HuShimin Hu
Jul 25, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexandre MorelDavid Sibon
Dec 2, 2017·Pediatric Blood & Cancer·Charlotte RigaudLaurence Brugieres

❮ Previous
Next ❯

Citations

Feb 16, 2020·Cancers·Lan Wang, Vivian Wai Yan Lui
Jan 4, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jianping KongAndrew L Feldman
Feb 9, 2021·Leukemia & Lymphoma·Rebeca MansoSocorro-María Rodríguez-Pinilla
Jan 9, 2021·Journal of Hematology & Oncology·Ming YiKongming Wu
Jan 21, 2021·Cancers·Elissa AndraosFabienne Meggetto
Jun 6, 2021·Journal of Experimental & Clinical Cancer Research : CR·Hao ZhangQuan Cheng
Aug 8, 2021·Human Pathology·Hideto IwafuchiUNKNOWN Lymphoma Committee and Pathology Committee of the Japanese Pediatric Leukemia/Lymphoma Study Group

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
flow cytometry

Software Mentioned

Graph
Pad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Jianping KongAndrew L Feldman
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Xiao-Wen Tang, De-Pei Wu
Laboratory Investigation; a Journal of Technical Methods and Pathology
Hesham M AminRaymond Lai
© 2021 Meta ULC. All rights reserved