PD-L1 overexpression in ampulla of Vater carcinoma and its pre-invasive lesions

Histopathology
Deborah SaraggiMassimo Rugge

Abstract

PD-1/PD-L1 checkpoint immunotherapy has been proposed recently as a promising treatment in relapsed/refractory disease, used eventually in combination with traditional chemotherapy in different cancer settings. To date, no data are available concerning PD-L1 expression in ampulla of Vater carcinoma and its pre-invasive lesions. We assessed the immunohistochemical expression of PD-L1 in a series of 26 ampullary adenocarcinomas, 50 ampullary dysplastic lesions and 10 normal duodenal mucosa samples. Moreover, in all cases DNA mismatch repair proteins status was investigated. PD-L1 was expressed in seven of 26 (26.9%) invasive carcinomas and three of 50 (6.0%) dysplastic samples. Most of the PD-L1-positive tumours (seven of 10) were intestinal-type and poorly differentiated (G3). The number of PD-L1-positive stromal lymphoid cells was significantly higher in dysplastic and invasive lesions than in the normal samples (P = 0.011). Nineteen dysplastic lesions and eight invasive carcinomas did not show any evident epithelial or stromal PD-L1 expression. Four of the carcinomas were mismatch repair-deficient and two of these were PD-L1-positive. Furthermore, mismatch repair-deficient lesions showed a significantly higher average of PD-L1...Continue Reading

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Citations

Nov 1, 2018·Virchows Archiv : an International Journal of Pathology·Samantha SarcognatoMaria Guido
Mar 20, 2020·Scandinavian Journal of Gastroenterology·Johannes KloseMartin Schneider
Nov 15, 2019·Virchows Archiv : an International Journal of Pathology·Matteo FassanFotios Loupakis
Dec 6, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stefano IndraccoloVittorina Zagonel

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