PD-loop technology: PNA openers at work

Expert Review of Molecular Diagnostics
Vadim V Demidov

Abstract

A concise survey of the emerging PD-loop technology is presented, which outlines several exemplary methods with robust DNA diagnostic potential: duplex DNA capture, topological DNA labeling, nondenaturing DNA sequencing and hybridization of molecular beacons to double-stranded DNA. Advantages of these new PNA-based assays over existing techniques for sequence-specific detection and manipulation of DNA duplexes are discussed. Future prospects for the further development of PD-loop technology are highlighted.

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Citations

Apr 23, 2004·Trends in Biochemical Sciences·Vadim V Demidov, Maxim D Frank-Kamenetskii
Dec 14, 2002·Trends in Biotechnology·Vadim V Demidov
May 15, 2002·Trends in Biotechnology·Natalia E Broude
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