Pd nanosheets with their surface coordinated by radioactive iodide as a high-performance theranostic nanoagent for orthotopic hepatocellular carcinoma imaging and cancer therapy

Chemical Science
Mei ChenNanfeng Zheng

Abstract

Radiolabeled nanoparticles (NPs), taking advantage of nanotechnology and nuclear medicine, have shown attractive potential for cancer diagnosis and therapy. However, the high background signal in the liver and long-term toxic effects of radioisotopes caused by the nonselective accumulation of radiolabeled nanoparticles in organs have become the major challenges. Here, we report a pH-sensitive multifunctional theranostic platform with radiolabeled Pd nanosheets through a simple mixture of ultra-small Pd nanosheets and radioisotopes utilizing the strong adsorption of 131I and 125I on their surfaces (denoted as 131I-Pd-PEG or 125I-Pd-PEG). Systematic studies reveal that the labeling efficiency is higher than 98% and the adsorption of radioiodine is more stable in an acidic environment. In vivo studies further validate the pH-dependent behavior of this platform and the enhanced retention of radioisotopes in tumors due to the acidic microenvironment. Single photon emission computed tomography (SPECT) images with zero background were successfully achieved in a subcutaneous 4T1 tumor model, an orthotopic LM3 tumor model, and even in a Mst1/2 double-knockout hepatoma model. Moreover, the application of radiolabeled Pd nanosheets for ph...Continue Reading

References

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Citations

Dec 18, 2018·Advanced Materials·Qinrui FuXiaoyuan Chen
Oct 8, 2019·Chemical Science·Chenyang ZhangYuliang Zhao
Feb 7, 2020·Nanoscale·Farhat NosheenWenping Hu
Oct 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yaya ChengXueji Zhang
Oct 14, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shahab Ranjbar BahadoriXiankai Sun
Nov 25, 2020·Nanoscale·Sarah De MarchiIsabel Pastoriza-Santos

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Methods Mentioned

BETA
xenograft
dissection
gene knockout

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