PDA: To treat or not to treat

Congenital Heart Disease
Meera N SankarW E Benitz

Abstract

Management of patent ductus arteriosus in extremely preterm infants remains a topic of debate. Treatment to produce ductal closure was widely practiced until the past decade, despite lack of evidence that it decreases morbidities or mortality. Meta-analyses of trials using nonsteroidal anti-inflammatory drugs have shown effectiveness in accelerating ductal closure, but no reduction in neonatal morbidities, regardless of agent used, indication, timing, gestational age, or route of administration. Surgical ligation closes the ductus but is associated with adverse effects. Recent experience with conservative approaches to treatment suggest improved neonatal outcomes and a high rate of spontaneous ductal closure after discharge. Careful postdischarge follow-up is important, however, because potential adverse effects of long-standing aortopulmonary shunts may be an indication for catheter-based ductal closure. Identification of extremely preterm infants at greatest risk of potential harm from a persistently patent ductus, who may benefit most from treatment are urgently needed.

References

Apr 15, 2003·European Journal of Pediatrics·Thor Willy Ruud Hansen
Feb 24, 2006·Journal of Perinatology : Official Journal of the California Perinatal Association·J T AttridgeP V Gordon
Jan 11, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Sophie VanhaesebrouckClaire Theyskens
Oct 14, 2008·American Journal of Perinatology·Sheri L NemerofskyJohn M Lorenz
Feb 26, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·W E Benitz
Jun 29, 2010·The Journal of Pediatrics·Matthew LaughonWilliam E Benitz
Jun 19, 2012·The Journal of Pediatrics·Lucia MireaUNKNOWN Canadian Neonatal Network
Jan 1, 2010·Journal of the Saudi Heart Association·Sabry GhanemMohamed Shafee
Dec 10, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Martin KluckowNick Evans
Aug 30, 2014·Archives of Disease in Childhood. Fetal and Neonatal Edition·Audrey RollandPascal Boileau
Dec 17, 2015·Pediatrics·William E Benitz, UNKNOWN COMMITTEE ON FETUS AND NEWBORN
Jul 28, 2016·The Journal of Pediatrics·Se In SungWon Soon Park
Jan 4, 2017·Early Human Development·J B LetshwitiJ Miletin
Jul 14, 2017·Pediatrics·Jana SemberovaZbynek Stranak
Jul 14, 2017·Pediatrics·William E Benitz
Jul 21, 2017·Seminars in Fetal & Neonatal Medicine·William E Benitz, Shazia Bhombal

❮ Previous
Next ❯

Citations

Sep 29, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·P ValiF Ing
Nov 7, 2019·World Journal of Pediatrics : WJP·Ting-Ting WangJiang-Qin Liu
Sep 4, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Ruben VaidyaRachana Singh
Aug 28, 2020·Frontiers in Pediatrics·Emel OkuluUNKNOWN Turkish Neonatal Society INTERPDA Study Group
Oct 8, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Meera N Sankar, William E Benitz
Oct 20, 2020·Frontiers in Pediatrics·Alain FraisseYogen Singh
Nov 24, 2020·Cardiology in the Young·Mariam ZaidiAmer Harky
Jan 29, 2021·Seminars in Fetal & Neonatal Medicine·Souvik MitraBradley C Johnston
Dec 4, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Brian C KingJonathan L Slaughter
Mar 7, 2021·Seminars in Fetal & Neonatal Medicine·Amir M Zayegh, Peter G Davis
Apr 17, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Susan M LopataJeff Reese
Aug 20, 2021·Pediatric Health, Medicine and Therapeutics·Marissa HennellySamia Aleem
Mar 7, 2021·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Leslie A ParkerMarina Magalhães

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.