PDA/Cu Bioactive Hydrogel with "Hot Ions Effect" for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing.

ACS Applied Materials & Interfaces
Qing XuJiang Chang

Abstract

Quick and effective sterilization of drug-resistant bacteria inevitably became an ever-growing global challenge. In this study, a multifunctional composite (PDA/Cu-CS) hydrogel mainly composed of polydopamine (PDA) and copper-doped calcium silicate ceramic (Cu-CS) was prepared. It was confirmed that PDA/copper (PDA/Cu) complexing in the composite hydrogel played a key role in enhancing the photothermal performance and antibacterial activity. Through a unique "hot ions effect", created by the heating of Cu ions through the photothermal effect of the composite hydrogel, the hydrogel showed high-efficiency, quick, and long-term inhibition of methicillin-resistant Staphylococcus aureus and Escherichia coli. In addition, the hydrogel possessed remarkable bioactivity to stimulate angiogenesis. The in vivo results confirmed that the "hot ions effect" of the composite hydrogel removed existing infection in the wound area efficiently and significantly promoted angiogenesis and collagen deposition during infectious skin wound healing. Our results suggested that the design of multifunctional hydrogels with "hot ions effect" may be an effective therapeutic approach for the treatment of infectious wounds.

References

Dec 24, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·B TolnerW N Konings
Jul 4, 2003·Science Progress·A D Russell
Jan 15, 2005·The Journal of Antimicrobial Chemotherapy·R S Howell-JonesD W Thomas
Sep 17, 2005·Journal of Materials Science. Materials in Medicine·F HeidenauH Gollwitzer
Oct 3, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Regina M S PereiraSérgio Paulo Bydlowski
Aug 29, 2009·Science·Michael A Fischbach, Christopher T Walsh
May 15, 2010·Journal of the American Academy of Dermatology·Christy Badgwell DohertyTheodore Rosen
Sep 9, 2011·Current Opinion in Microbiology·Michael A Fischbach
Sep 17, 2013·Medicinal Research Reviews·Stalin SelvarajUma Maheswari Krishnan
Jun 24, 2015·ACS Applied Materials & Interfaces·Sung Han KimSung Young Park
Aug 27, 2015·Journal of Pharmaceutical Sciences·Joshua Boateng, Ovidio Catanzano
Feb 12, 2017·Science·Irit Levin-ReismanNathalie Q Balaban
Apr 5, 2017·The Journal of Infectious Diseases·Latania K Logan, Robert A Weinstein
May 4, 2017·JAMA Surgery·Sandra I Berríos-TorresUNKNOWN Healthcare Infection Control Practices Advisory Committee
Jul 14, 2017·Environmental Science and Pollution Research International·Jelena MilenkovicNevenka Rajic
May 31, 2018·Microbial Pathogenesis·Kenneth S BrandenburgJonathan F McAnulty
May 31, 2018·Advanced Healthcare Materials·Yanling ZhouJiang Chang
Sep 21, 2018·Journal of Biomaterials Science. Polymer Edition·Cheng ZhaoJianan Ren
Dec 16, 2018·Colloids and Surfaces. B, Biointerfaces·Tingting YangXuanyong Liu
Jul 26, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Amal G Al-Bakri, Nouf N Mahmoud

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