Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation

Human Pathology
Akifumi HayashiM Tsuneyoshi

Abstract

Intraductal papillary mucinous neoplasm is characterized by cystically dilated main and/or branch pancreatic duct with mucus. According to the degree of atypia, intraductal papillary mucinous neoplasm is classified into 3 groups: adenoma, borderline, and carcinoma. Furthermore, intraductal papillary mucinous neoplasm is considered to progress through an adenoma-carcinoma sequence like colorectal carcinoma. Programmed cell death 4 is a recently identified tumor suppressor that was found to inhibit translation. Programmed cell death 4 has been reported to inhibit tumorigenesis, tumor progression, proliferation, invasion, and metastasis in several human malignancies. We examined 108 cases of intraductal papillary mucinous neoplasm by immunohistochemistry and revealed that programmed cell death 4 expression was recognized in both the nucleus and cytoplasm in intraductal papillary mucinous neoplasm. The positive rate of programmed cell death 4 was 79%, 43%, and 10% in adenoma, borderline, and carcinoma, respectively. The positive rate of programmed cell death 4 decreased from adenoma to carcinoma (P < .0001, both adenoma versus borderline and borderline versus carcinoma), indicating that programmed cell death 4 might inhibit tumor p...Continue Reading

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Citations

Oct 11, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yuichi NagaoHiroshi Hashimoto
Jul 21, 2011·Carcinogenesis·Tobias SchmidBernhard Brüne
Mar 1, 2012·North American Journal of Medical Sciences·Ake Andrén-Sandberg
Feb 1, 2011·North American Journal of Medical Sciences·Ake Andrén-Sandberg
Jul 23, 2011·Human Pathology·Chanjuan Shi, Ralph H Hruban
Jan 31, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Katsuya MorimatsuYoshinao Oda
Feb 3, 2018·Journal of Oral and Maxillofacial Pathology : JOMFP·Karishma M Desai, Alka D Kale
May 29, 2018·Biology of the Cell·Qing Wang, Hsin-Sheng Yang

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