PdCl2(HNMe2)2-catalyzed highly selective cross [2 + 2 + 2] cyclization of alkynoates and alkenes under molecular oxygen

The Journal of Organic Chemistry
Yanxia ShenZhengwang Chen

Abstract

In the course of our study on palladium-catalyzed aerobic oxidation synthesis, we found that the PdCl(2)/O(2)/DMF system consistently experienced DMF hydrolysis to afford PdCl(2)(HNMe(2))(2), which is the real active catalyst for the aerobic oxidation. Although in situ DMF hydrolysis has been widely used in generating supramolecular assembly architectures, as far as we know, it is the first successful example to utilize PdCl(2)(HNMe(2))(2) in synthetic reactions. The highly selective cross [2 + 2+2] cyclization of alkynoates and different alkenes with electron-withdrawing groups could be smoothly catalyzed by PdCl(2)(HNMe(2))(2)/O(2)/DMF to afford the corresponding functionalized pentasubstituted benzenes in good to excellent yields (70-97%). The extension of alkyne surrogates for cross [2 + 2 + 2] cyclization from special alkenes with leaving groups to simple alkenes under molecular oxygen led to a paradigm shift in arene synthesis.

References

Jan 18, 2006·The Journal of Organic Chemistry·Satoko KezukaRyo Takeuchi
May 27, 2008·Journal of the American Chemical Society·Hayato TsujiEiichi Nakamura
Aug 9, 2008·Chemical Communications : Chem Comm·Roberto BalliniLuciano Barboni
Feb 21, 2009·Angewandte Chemie·Brandon R Galan, Tomislav Rovis

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Citations

Feb 27, 2016·Chemistry : a European Journal·Gema Domínguez, Javier Pérez-Castells
Apr 17, 2019·ChemSusChem·Miao HuHuanfeng Jiang
May 15, 2020·Chemical Communications : Chem Comm·Penghua LiMin Shi
Jul 31, 2012·Accounts of Chemical Research·Wanqing Wu, Huanfeng Jiang

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