PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway

Analytical Cellular Pathology (Amsterdam)
Xiang-yu KongYongxing Zhang

Abstract

To assess the expression levels of exchange protein 1 directly activated by cAMP (Epac1) and phosphodiesterase 4 (PDE4) in rectal carcinoma, and their associations with clinicopathological indexes. In addition, the associations of PDE4 and Epac1 with A-kinase anchor protein 95, connexin 43, cyclin D1, and cyclin E1 were evaluated. The PV-9000 two-step immunohistochemistry method was used to determine protein expression in 44 rectal carcinoma tissue samples and 16 paracarcinoma tissue specimens. The positive rate of PDE4 protein expression in rectal carcinoma tissues was higher than that of paracarcinoma tissues (59.09% vs. 12.5%, P < 0.05). Similar findings were obtained for Epac1 (55% vs. 6.25%, P < 0.05). No significant associations of PDE4 and Epac1 with degree of differentiation, histological type, and lymph node metastasis were found in rectal carcinoma (P > 0.05). Correlations between PDE4 and Epac1, PDE4 and Cx43, PDE4 and cyclin E1, and Epac1 and Cx43 were observed (all P < 0.05). There was no correlation between the other protein pairs examined (P > 0.05). PDE4 and Epac1 expression levels are increased in rectal carcinoma tissues, suggesting that the two proteins may be involved in the development of this malignancy. M...Continue Reading

References

Dec 18, 1998·Science·H KawasakiA M Graybiel
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela L AsirvathamDaniel W Carr
Aug 23, 2005·The Prostate·Amanda W TateMagnus Edlund
Jul 1, 2006·Trends in Molecular Medicine·George McConnachieJohn D Scott
Jun 15, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Coskun UlucanYoshihiro Ishikawa
Nov 17, 2009·British Journal of Pharmacology·Maria GrandochMartina Schmidt
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Martijn Gloerich, Johannes L Bos
Jun 30, 2010·Pflügers Archiv : European journal of physiology·Nicolas DuquesnesBertrand Crozatier
Oct 7, 2014·Expert Opinion on Therapeutic Patents·Ana Martinez, Carmen Gil

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Citations

Sep 10, 2020·International Journal of Molecular Sciences·Nadine WehbeElias Baydoun
Nov 2, 2019·Biochemical Society Transactions·Urszula Luchowska-StańskaGraeme Barker
Jan 1, 2021·Cancers·Chang-Xu ChenJean X Jiang

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BETA
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SPSS13

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