PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying

Molecular and Cellular Endocrinology
E MeelkopLiliane Schoofs

Abstract

In Caenorhabditis elegans, pdfr-1 encodes three receptors of the secretin receptor family. These G protein-coupled receptors are activated by three neuropeptides, pigment dispersing factors 1a, 1b and 2, which are encoded by pdf-1 and pdf-2. We isolated a PDF receptor loss-of-function allele (lst34) by means of a mutagenesis screen and show that the PDF signaling system is involved in locomotion and egg-laying. We demonstrate that the pdfr-1 mutant phenocopies the defective locomotor behavior of the pdf-1 mutant and that pdf-1 and pdf-2 behave antagonistically. All three PDF receptor splice variants are involved in the regulation of locomotor behavior. Cell specific rescue experiments show that this pdf mediated behavior is regulated by neurons rather than body wall muscles. We also show that egg-laying patterns of pdf-1 and pdf-2 mutants are affected, but not those of pdfr-1 mutants, pointing to a novel role for the PDF-system in the regulation of egg-laying.

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Citations

Dec 3, 2014·Experimental Gerontology·Giel DetienneLiesbet Temmerman
Nov 21, 2014·Critical Reviews in Biochemistry and Molecular Biology·Michael KunstMichael N Nitabach
Mar 12, 2015·ELife·Patrick LaurentMario de Bono
Oct 9, 2012·Neuron·Paul H Taghert, Michael N Nitabach
Nov 11, 2015·Scientific Reports·Liesbeth Van RompayLiesbet Temmerman
Feb 24, 2017·Journal of Neurophysiology·Richard J McCloskeyChristopher Fang-Yen
Jun 27, 2015·Genes, Brain, and Behavior·A HerreroD A Golombek
Sep 12, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Yee Lian ChewWilliam R Schafer
Aug 18, 2017·NPJ Science of Learning·Evan L ArdielCatharine H Rankin
Aug 28, 2021·International Journal for Parasitology·Fiona M McKayAngela Mousley

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