PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

Oncogene
Jeffrey P Zwerner, W A May

Abstract

The aberrant transcription factors associated with many human malignancies function by deregulation of tumorigenic pathways. However, identification of these pathways has come slowly. Virtually all cases of Ewing's Sarcoma and peripheral Primitive Neuroectodermal Tumor (PNET) are associated with aberrant transcription factors which fuse amino-terminal EWS with the DNA binding moiety of an ETS transcription factor (FLI-1 in 90% of cases). Attempts to identify the downstream targets of these chimeras in the Ewing Family Tumors (EFT) on the basis of differential gene regulation have produced little association with tumor biology. As an alternative approach, we have used highly efficient retroviral systems to biologically screen cDNA derived from cells transformed by EWS/FLI-1. We have identified the recently described PDGF-C as target of EWS/ETS transcriptional deregulation. This transcriptional deregulation is specific to EWS/FLI. PDGF-C possesses substantial biologic activity in vitro and in vivo. It is expressed in EFT cell lines and in primary tumors. Within these EFT cell lines, PDGF-C expression is dependent upon EWS/FLI activity. These results suggest that PDGF-C may be a significant mediator of EWS/FLI driven oncogenesis.

References

Feb 1, 1995·Molecular and Cellular Biology·I WhiteheadR Kay
Jul 1, 1994·Klinische Pädiatrie·H KovarR Windhager
Nov 10, 1994·Nature·T H Rabbitts
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W A MayC T Denny
Dec 17, 1997·Nature Genetics·W A MayC T Denny
Sep 4, 1998·Science·T C HeK W Kinzler
Mar 13, 1999·Science·G J HannonD Beach
Sep 15, 1999·Genes & Development·R MaestroG J Hannon
Nov 24, 1999·The Journal of Experimental Medicine·J D HudsonD H Beach
Jan 7, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E de Alava, W L Gerald
May 12, 2000·Nature Cell Biology·X LiU Eriksson
Jun 24, 2000·Nature·O G Vukmirovic, S M Tilghman
Aug 30, 2000·Nature·C M PerouD Botstein

❮ Previous
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Citations

Jul 9, 2005·Cancer Immunology, Immunotherapy : CII·A BorowskiE M Schneider
Oct 26, 2005·Current Treatment Options in Oncology·Nancy R McAllister, Stephen L Lessnick
Oct 22, 2003·Experimental Cell Research·Jeffrey P ZwernerWilliam A May
Oct 18, 2003·Seminars in Cancer Biology·Heinrich KovarSarka Pospisilova
Mar 26, 2003·Cytokine & Growth Factor Reviews·Xuri Li, Ulf Eriksson
Dec 18, 2007·Oncogene·J P ZwernerW A May
Dec 12, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Claudia SeikritTammo Ostendorf
Jul 20, 2002·Current Opinion in Oncology·Jeannette L Bennicelli, Frederic G Barr
Jan 22, 2005·Current Opinion in Pediatrics·Aykut Uren, Jeffrey A Toretsky
Apr 14, 2012·Advances in Anatomic Pathology·Elizabeth G DemiccoAlexander J Lazar
May 16, 2003·Molecular and Cellular Biology·Benjamin DeneenChristopher T Denny
Jul 25, 2009·BMC Genomics·Uros MidicVladimir N Uversky
May 1, 2009·PloS One·Maximilian KauerHeinrich Kovar
Oct 7, 2010·Indian Journal of Orthopaedics·Saral S Desai, Nirmala A Jambhekar
Mar 25, 2006·Future Oncology·Aykut Uren, Jeffrey A Toretsky
Feb 8, 2002·Archives of Biochemistry and Biophysics·Carl-Henrik HeldinArne Ostman
Mar 26, 2011·Sarcoma·Mona S JahromiJoshua D Schiffman
Mar 20, 2010·Journal of Oncology·R L RandallJ D Schiffman
Aug 26, 2014·Future Oncology·Janna PaulssonArne Östman
Sep 29, 2011·Annual Review of Pathology·Stephen L Lessnick, Marc Ladanyi
Feb 22, 2002·Genesis : the Journal of Genetics and Development·Hao DingAndras Nagy
Aug 26, 2010·Expert Review of Anticancer Therapy·Joseph ChaoGeorge Somlo
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·S John Weroha, Paul Haluska
Nov 19, 2008·Seminars in Diagnostic Pathology·José Luis OrdóñezEnrique de Alava
Jul 1, 2008·Experimental Cell Research·Jian ZhaoMonica Nistér
Nov 20, 2015·Frontiers in Oncology·Monika Ehnman, Olle Larsson
Feb 15, 2007·Pathology, Research and Practice·Ingu DoYong-Koo Park
Jan 26, 2007·Cancer Letters·Nicolò Riggi, Ivan Stamenkovic
Sep 17, 2004·The EMBO Journal·Linda FredrikssonUlf Eriksson
Jun 9, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Howard A ChanskyLiu Yang
Jan 31, 2003·Genes, Chromosomes & Cancer·Goichi WatanabeTakashi Tokino
Mar 30, 2006·International Journal of Cancer. Journal International Du Cancer·Stefania BeniniKatia Scotlandi
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Marta MendiolaJavier Alonso
Jul 2, 2009·International Journal of Cancer. Journal International Du Cancer·Yukio YamanoHideki Tanzawa
Jun 23, 2004·Cytokine & Growth Factor Reviews·Linda FredrikssonUlf Eriksson
Jan 31, 2006·Experimental Cell Research·Laila J ReigstadJohan R Lillehaug
Oct 13, 2015·Disease Markers·Zhi-Ping YangYe Zhang

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