PDGF-dependent β-catenin activation is associated with abnormal pulmonary artery smooth muscle cell proliferation in pulmonary arterial hypertension

FEBS Letters
Jack TakahashiVinicio de Jesus Perez

Abstract

Pulmonary arterial hypertension (PAH) is characterized by excessive pulmonary arterial smooth muscle cells (PASMCs) growth, partially in response to PDGF-BB but whether this is dependent on β-catenin (βC) activation is unclear. Compared to healthy cells, PAH PASMCs demonstrate higher levels of proliferation both at baseline and with PDGF-BB that correlate with GSK3β dependent βC activation. We show that βC knockdown but not Wnt5a stimulation reduces PDGF-BB dependent growth and normalizes PAH PASMCs proliferation. These findings support that cross-talk between PDGF and Wnt signaling modulates PASMC proliferation and suggest that βC targeted therapies could treat abnormal vascular remodeling in PAH.

References

Oct 4, 2005·The Journal of Clinical Investigation·Ralph Theo SchermulyFriedrich Grimminger
Sep 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael J NemethDavid M Bodine
Apr 3, 2008·The Journal of Clinical Investigation·Georg HansmannMarlene Rabinovitch
Apr 19, 2008·American Journal of Respiratory and Critical Care Medicine·Frédéric PerrosMarc Humbert
Jun 17, 2008·American Journal of Respiratory and Critical Care Medicine·Pradeep R RaiNorbert F Voelkel
Jul 4, 2008·The Journal of Clinical Investigation·Marlene Rabinovitch
Oct 1, 2008·Circulation·Evangelos D MichelakisMarlene Rabinovitch
Jun 29, 2010·American Journal of Respiratory and Critical Care Medicine·Hossein A GhofraniSteve Pascoe
Jan 5, 2011·Circulation Research·Aikaterini TsaousiSarah J George
Jan 12, 2011·The Journal of Cell Biology·Vinicio A de Jesus PerezMarlene Rabinovitch
Jan 10, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Rachel J DaviesNicholas W Morrell
Feb 7, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jose Gomez-ArroyoNorbert F Voelkel
Jun 12, 2012·Cell·Hans Clevers, Roel Nusse
Aug 29, 2012·Expert Opinion on Therapeutic Targets·Sabina Antonela Antoniu
Sep 7, 2012·Cold Spring Harbor Perspectives in Biology·Karl Willert, Roel Nusse
Sep 27, 2012·Circulation Research·Vinicio A de Jesus PerezMarlene Rabinovitch
Nov 13, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xiao-Min YuChen Wang
Sep 17, 2013·Seminars in Respiratory and Critical Care Medicine·Laurent GodinasDavid Montani
Jun 21, 2014·Pharmacological Reports : PR·Magdalena Jasińska-Stroschein, Daria Orszulak-Michalak

❮ Previous
Next ❯

Citations

Jul 7, 2016·Clinical Lymphoma, Myeloma & Leukemia·Marko LucijanicRajko Kusec
Jun 16, 2016·American Journal of Respiratory and Critical Care Medicine·Bradley A MaronMarc A Simon
Feb 18, 2017·Current Opinion in Hematology·Lina Badimon, Maria Borrell-Pages
Dec 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philip TannenbergKarin Tran-Lundmark
Sep 30, 2016·Pulmonary Circulation·Keytam S AwadMargaret MacLean
Feb 14, 2018·Journal of the American Heart Association·Isabella AlbaneseAdel Schwertani
Nov 14, 2018·Journal of Cellular and Molecular Medicine·Chenchen FengChunquan Li
Dec 17, 2017·Pharmacological Reviews·Sébastien FoulquierW Matthijs Blankesteijn
Jul 11, 2018·Cellular & Molecular Biology Letters·Jingjing LuJiewen Zhang
Jan 1, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alice BourgeoisOlivier Boucherat
Jan 8, 2020·Pulmonary Circulation·Mattias ArvidssonGöran Rådegran
Aug 12, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Xin YunLarissa A Shimoda
Jun 16, 2018·Experimental and Therapeutic Medicine·Wencheng YuWeina Ji
Oct 23, 2020·Journal of Cellular and Molecular Medicine·Zhaohua ZhangYun Luan
Apr 9, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Thor UelandArne K Andreassen
Jun 4, 2019·Journal of Molecular and Cellular Cardiology·Alexandre ValléeYves Lecarpentier
Jul 11, 2021·Journal of Cellular and Molecular Medicine·Rong SongShang-Jie Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Frédéric PerrosMarc Humbert
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
Wen-Cheng Yu, Cai-Hong Guo
American Journal of Physiology. Lung Cellular and Molecular Physiology
Xiao-Min YuChen Wang
Revue des maladies respiratoires
Saadia Eddahibi, Serge Adnot
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Yuanyuan WuManxiang Li
© 2022 Meta ULC. All rights reserved