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PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow

PloS One

Oct 12, 2012

Christina S Alves, Konstantinos Konstantopoulos

Abstract

Fibrin(ogen) mediates sustained tumor cell adhesion and survival in the pulmonary vasculature, thereby facilitating the metastatic dissemination of tumor cells. CD44 is the major functional fibrin receptor on colon carcinoma cells. Growth factors, such as platelet-derived growth factor ...read more

Mentioned in this Paper

Pathologic Cytolysis
SELP gene
Tumor Cells, Uncertain Whether Benign or Malignant
Flow Cytometry
Immunofluorescence Assay
Fibrin Measurement
Chondroitin
Sulfates, Inorganic
Stress, Mechanical
Microscopy, Video
Paper Details
References
  • References26
  • Citations3
123
  • References26
  • Citations3
1

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Related Papers

Biophysical Journal

Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen)

Biophysical JournalSeptember 6, 2012
Phrabha S RamanKonstantinos Konstantopoulos
© 2020 Meta ULC. All rights reserved

PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow

PloS One

Oct 12, 2012

Christina S Alves, Konstantinos Konstantopoulos

PMID: 23056168

DOI: 10.1371/journal.pone.0041472

Abstract

Fibrin(ogen) mediates sustained tumor cell adhesion and survival in the pulmonary vasculature, thereby facilitating the metastatic dissemination of tumor cells. CD44 is the major functional fibrin receptor on colon carcinoma cells. Growth factors, such as platelet-derived growth factor ...read more

Mentioned in this Paper

Pathologic Cytolysis
SELP gene
Tumor Cells, Uncertain Whether Benign or Malignant
Flow Cytometry
Immunofluorescence Assay
Fibrin Measurement
Chondroitin
Sulfates, Inorganic
Stress, Mechanical
Microscopy, Video

Similar Papers Found In These Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Selectin–Mediating Drugs

Selectins are a class of lectin molecule expressed on endothelial cells that permit leukocyte rolling and eventual extravasation. Targeting selectins may prove useful in modifying inflammation and for drug delivery to the endothelium.

Related Papers

Biophysical Journal

Distinct kinetic and molecular requirements govern CD44 binding to hyaluronan versus fibrin(ogen)

Biophysical JournalSeptember 6, 2012
Phrabha S RamanKonstantinos Konstantopoulos
Paper Details
References
  • References26
  • Citations3
123
  • References26
  • Citations3
1
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