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PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow

PloS One

Oct 8, 2012

Christina S Alves, Konstantinos Konstantopoulos

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Abstract

Fibrin(ogen) mediates sustained tumor cell adhesion and survival in the pulmonary vasculature, thereby facilitating the metastatic dissemination of tumor cells. CD44 is the major functional fibrin receptor on colon carcinoma cells. Growth factors, such as platelet-derived growth factor ...read more

Mentioned in this Paper

Fibrinogen Assay
L-Selectin
Flow Cytometry
Deficiency Diseases
Post-Translational Protein Processing
Dimyristoylphosphatidylcholine
Platelet-derived Growth Factor Receptor Binding Activity
Ligands
CD44 gene
Lipids
Paper Details
References
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  • PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow

    PloS One

    Oct 8, 2012

    Christina S Alves, Konstantinos Konstantopoulos

    PMID: 23056168

    DOI: 10.1371/journal.pone.0041472

    Abstract

    Fibrin(ogen) mediates sustained tumor cell adhesion and survival in the pulmonary vasculature, thereby facilitating the metastatic dissemination of tumor cells. CD44 is the major functional fibrin receptor on colon carcinoma cells. Growth factors, such as platelet-derived growth factor ...read more

    Mentioned in this Paper

    Fibrinogen Assay
    L-Selectin
    Flow Cytometry
    Deficiency Diseases
    Post-Translational Protein Processing

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    Paper Details
    References
    • References26
    • Citations2
    • References26
    • Citations2
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