PDGFBB promotes PDGFRα-positive cell migration into artificial bone in vivo

Biochemical and Biophysical Research Communications
Shigeyuki YoshidaTakeshi Miyamoto

Abstract

Bone defects caused by traumatic bone loss or tumor dissection are now treated with auto- or allo-bone graft, and also occasionally by artificial bone transplantation, particularly in the case of large bone defects. However, artificial bones often exhibit poor affinity to host bones followed by bony union failure. Thus therapies combining artificial bones with growth factors have been sought. Here we report that platelet derived growth factor bb (PDGFBB) promotes a significant increase in migration of PDGF receptor α (PDGFRα)-positive mesenchymal stem cells/pre-osteoblastic cells into artificial bone in vivo. Growth factors such as transforming growth factor beta (TGFβ) and hepatocyte growth factor (HGF) reportedly inhibit osteoblast differentiation; however, PDGFBB did not exhibit such inhibitory effects and in fact stimulated osteoblast differentiation in vitro, suggesting that combining artificial bones with PDGFBB treatment could promote host cell migration into artificial bones without inhibiting osteoblastogenesis.

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Citations

Feb 15, 2015·Mechanisms of Ageing and Development·Ping Kwan
Oct 13, 2016·Scientific Reports·Mayu MoritaTakeshi Miyamoto
Jun 13, 2018·International Journal of Molecular Sciences·Giulia BattafaranoAndrea Del Fattore
Oct 21, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhifa WangBin Liu

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