Abstract
Bone defects caused by traumatic bone loss or tumor dissection are now treated with auto- or allo-bone graft, and also occasionally by artificial bone transplantation, particularly in the case of large bone defects. However, artificial bones often exhibit poor affinity to host bones followed by bony union failure. Thus therapies combining artificial bones with growth factors have been sought. Here we report that platelet derived growth factor bb (PDGFBB) promotes a significant increase in migration of PDGF receptor α (PDGFRα)-positive mesenchymal stem cells/pre-osteoblastic cells into artificial bone in vivo. Growth factors such as transforming growth factor beta (TGFβ) and hepatocyte growth factor (HGF) reportedly inhibit osteoblast differentiation; however, PDGFBB did not exhibit such inhibitory effects and in fact stimulated osteoblast differentiation in vitro, suggesting that combining artificial bones with PDGFBB treatment could promote host cell migration into artificial bones without inhibiting osteoblastogenesis.
References
Nov 23, 1989·Nature·T NakamuraS Shimizu
Nov 12, 1965·Science·M R Urist
Aug 16, 1984·Biochemical and Biophysical Research Communications·T NakamuraA Ichihara
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·K MatsumotoT Nakamura
May 30, 1997·Cell·T KomoriT Kishimoto
May 30, 1997·Cell·F OttoM J Owen
May 31, 2001·Kidney International·K Matsumoto, T Nakamura
Oct 17, 2001·Journal of Orthopaedic Trauma·G H WestrichD L Helfet
Jan 17, 2002·Cell·Kazuhisa NakashimaBenoit de Crombrugghe
Jun 3, 2005·The Journal of Bone and Joint Surgery. American Volume·M F TermaatH J Th M Haarman
Sep 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yuuki ImaiKunio Takaoka
Dec 8, 2005·Journal of Periodontology·Myron NevinsSamuel E Lynch
Jun 1, 2006·International Orthopaedics·M HirataT Kubo
Mar 20, 2008·The Journal of Bone and Joint Surgery. American Volume·Jeffrey O HollingerGary E Friedlaender
Oct 21, 2009·The Journal of Experimental Medicine·Satoru MorikawaYumi Matsuzaki
Nov 17, 2009·Biomaterials·Toshiki KawasakiYoshiaki Toyama
Dec 8, 2010·Journal of Clinical Periodontology·Avula JayakumarSayini Pavan Kumar
Dec 14, 2011·The Journal of Bone and Joint Surgery. American Volume·Chad Myeroff, Michael Archdeacon
Citations
Apr 16, 2013·PLoS Biology·Hyun-Ju ChoHyo-Soo Kim
Dec 9, 2014·Cell Adhesion & Migration·Lavinia CasatiAlessandra Colciago
Feb 15, 2015·Mechanisms of Ageing and Development·Ping Kwan
Oct 13, 2016·Scientific Reports·Mayu MoritaTakeshi Miyamoto
Aug 15, 2018·Molecular Medicine Reports·Qi LiuZubing Li
Sep 11, 2014·Biological Chemistry·Yvonne SchmidtGünter Finkenzeller
Jun 13, 2018·International Journal of Molecular Sciences·Giulia BattafaranoAndrea Del Fattore
Oct 21, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Zhifa WangBin Liu
Jan 1, 2014·International Journal of Molecular Medicine·Emiko AomatsuAkira Ishisaki