Pd(II)-Catalyzed C3-Selective Arylation of Pyridine with (Hetero)arenes

Organic Letters
Guo-Lin GaoJin-Quan Yu

Abstract

Palladium catalyzed, nondirected C3-selective arylation of pyridines with arenes and heteroarenes in the presence of 1,10-phenanthroline as the ligand has been developed. The optimized conditions allow for a highly C3-selective arylation of pyridines, affording various 3,3'-bipyridines and 3-arylpyridines.

References

Jan 28, 2006·The Journal of Organic Chemistry·Liang WangYanguang Wang
Jan 27, 2007·Journal of Medicinal Chemistry·Brian L HodousHuilin Zhao
Feb 1, 2007·Journal of the American Chemical Society·Soya GamseyBakthan Singaram
Jun 26, 2007·The Journal of Organic Chemistry·Shengyin Shi, Yuhong Zhang
Aug 22, 2008·Journal of the American Chemical Society·Liang Zhang, Jie Wu
Feb 4, 2010·The Journal of Organic Chemistry·Steven M RadersJohn G Verkade
Sep 9, 2010·Journal of the American Chemical Society·Yoshiaki NakaoTamejiro Hiyama
Dec 2, 2010·The Journal of Organic Chemistry·David LapointeKeith Fagnou
Jan 22, 2011·The Journal of Organic Chemistry·Mostafa BaghbanzadehC Oliver Kappe
Mar 11, 2011·The Journal of Organic Chemistry·Hu ChenChien-Hong Cheng
Apr 5, 2011·Journal of the American Chemical Society·Kyle W QuasdorfNeil K Garg
Nov 9, 2011·Journal of the American Chemical Society·Mengchun YeJin-Quan Yu
May 26, 2012·Chemical Communications : Chem Comm·Wen-Ching ChenTiow-Gan Ong
Aug 17, 2012·Organic Letters·María José IglesiasM Carmen Nicasio
Mar 27, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ulkü YılmazNihat Sireci

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Citations

Jan 14, 2017·Chemical Reviews·Yudong YangJingsong You
Apr 27, 2017·Chemical Reviews·Kei MurakamiKenichiro Itami
Jan 24, 2017·Chemical Science·Jean-Nicolas DesrosiersChris H Senanayake
Jul 26, 2019·Angewandte Chemie·Marek GrzybowskiDaniel T Gryko

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