Pd(II)-catalyzed conversion of styrene derivatives to acetals: impact of (-)-sparteine on regioselectivity

Organic Letters
Amy M BalijaMatthew S Sigman

Abstract

[reaction: see text] Pd[(-)-sparteine]Cl(2) catalyzes the formation of dialkyl acetals from styrene derivatives with Markovnikov regioselectivity. The substrate scope of this reaction has been investigated, and initial mechanistic studies indicate that the reaction proceeds through an enol ether intermediate and a Pd-hydride.

References

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Citations

Mar 31, 2015·Chemistry : a European Journal·Kate L BaddeleyMatthew J Cook
Apr 4, 2008·Organic & Biomolecular Chemistry·Jiajing TanZhiyong Wang
Aug 25, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Adham AhmedHaifei Zhang
Sep 24, 2020·Organic & Biomolecular Chemistry·Shuang YangZhenhua Ding
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Feb 24, 2012·Chemical Communications : Chem Comm·Abhishek Dutta Chowdhury, Goutam Kumar Lahiri
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Aug 25, 2006·Organic Letters·Candace N Cornell, Matthew S Sigman
May 23, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Yasuyuki Ura
Oct 12, 2021·Organic Letters·Liangkun PanYing-Yeung Yeung

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