PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

Oncotarget
S X LianJ Zhu

Abstract

The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.

References

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Citations

Aug 24, 2016·Genes & Cancer·Katherine M MoxleyMagdalena Bieniasz
Oct 25, 2017·Cancers·Aikaterini Emmanouilidi, Marco Falasca
May 20, 2020·Therapeutic Advances in Medical Oncology·Galatea KallergiSabine Kasimir-Bauer
Dec 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhihao WuMin Zheng
Mar 20, 2021·Bioscience Reports·Xiuxiu WangHongmin Li

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Methods Mentioned

BETA
transfection
PCR
electrophoresis
xenograft

Software Mentioned

Graphpad prism
SPSS

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