Pd/Phosphoramidite Thioether Complex-Catalyzed Asymmetric N-Allylic Alkylation of Hydrazones with Allylic Acetates

Organic Letters
Bin LuWen-Jing Xiao

Abstract

A general and efficient Pd/phosphoramidite thioether complex-catalyzed asymmetric N-allylic alkylation of hydrazones with allylic acetates has been developed for the first time. The reaction allows for the preparation of various valuable N-substituted hydrazones with generally good yields and excellent enantioselectivities. Minor structural modification of the ligand resulted in opposite enantiomers, enabling enantiodivergent synthesis of products by the same catalytic system.

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