Peanut ingestion increases rectal proliferation in individuals with mucosal expression of peanut lectin receptor

Gastroenterology
S D RyderJonathan M Rhodes

Abstract

The Thomsen-Friedenreich blood group antigen (galactose beta 1,3-N-acetyl galactosamine alpha-) acts as an oncofetal antigen in the colonic epithelium, with low expression in normal adult epithelia but increasing to fetal levels of expression in hyperplasia or malignancy. Peanut lectin is one of the commonest dietary lectins that binds this antigen. The aim of this study was to determine whether peanut ingestion can alter rectal epithelial proliferation. Thirty-six patients with normal colonic mucosa consumed 100 g of peanuts each day for 5 days. Rectal mitotic index was measured before and after ingestion, and changes in proliferation were correlated with immunohistochemical detection of lectin receptor expression by colonocytes and fecal lectin activity as measured by hemagglutination assay. Peanut ingestion caused a 41% increase in rectal mucosal proliferation in individuals with macroscopically normal mucosa who express TF antigen in their rectal mucosae (10 of 36 patients studied). The proliferative response correlated with fecal hemagglutinating activity, and peanut lectin could be shown immunohistochemically within the rectal mucosa. The common expression of galactose beta 1,3-N-acetyl galactosamine alpha- by hyperplasti...Continue Reading

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Citations

May 19, 2011·Applied Biochemistry and Biotechnology·Ram Sarup SinghAshok Kumar Tiwary
Feb 14, 2002·Trends in Molecular Medicine·Jonathan M Rhodes, Barry J Campbell
Jun 10, 2000·Alimentary Pharmacology & Therapeutics·M JordinsonJ Calam
Mar 6, 2002·Alimentary Pharmacology & Therapeutics·M SasakiR A Goodlad
Sep 27, 2005·Critical Reviews in Food Science and Nutrition·Elvira González De Mejía, Valentin I Prisecaru
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Dec 5, 2015·Expert Opinion on Drug Delivery·John Youshia, Alf Lamprecht
Apr 25, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Zhen LiuJin-Ku Bao
Feb 5, 2009·Journal of Applied Microbiology·G Zárate, A Perez Chaia
Jul 6, 2004·Gastroenterology·Helen M MartinJonathan M Rhodes
Jun 10, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brice MoulariAlf Lamprecht
Jul 5, 2005·Expert Opinion on Investigational Drugs·M JordinsonM Pignatelli
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Feb 1, 2020·The Proceedings of the Nutrition Society·Jonathan M Rhodes
Nov 22, 2008·Biochemical Society Transactions·Jonathan M RhodesLu-Gang Yu
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Jun 22, 2021·Frontiers in Bioengineering and Biotechnology·Wunan ZhangAna Beloqui
Dec 23, 2003·Alimentary Pharmacology & Therapeutics·E D J CourtneyR J Leicester

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